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Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
1 - 10 of 62
- Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targetsFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- GAINING INSIGHT IN THE MUTATIONAL PROFILE OF PT-DLBCL AND ASSESSING ITS BIOLOGICAL EFFECTS AND TRANSFORMING POTENTIALFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Degradation of CDK1 and HDACs as a strategy to treat T-cell malignanciesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Uncovering mechanisms of TLX1/TLX3 oncogenic cooperation in leukemiaFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- EZH2 as a transcriptional activator in T-ALLFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- TLX transcriptional complexes in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Mechanisms of resistance to current treatment of acute myeloid leukemiaFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Oncogene cooperation enhancing TLX1 positive leukemia developmentFrom1 Sep 2022 → TodayFunding: Other federal public and semi-governmental institutions
Publications
161 - 170 of 200
- JAK3 specific kinase inhibitors: when specificity is not enough(2011)
Authors: Jan Cools
Pages: 277 - 278 - The Kinase Inhibitor TKI258 Is Active Against the Novel CUX1 FGFR1 Fusion Detected In a Patient with T Lymphoblastic Leukemia/Lymphoma and t(7,8)(q22,p11)(2010)
Authors: Bartosz Wasag, Els Lierman, Peter Meeus, Jan Cools, Peter Vandenberghe
Pages: 1119 - 1119 - PHF6 mutations in adult acute myeloid leukemia(2010)
Authors: Peter Vandenberghe, Jan Cools
Pages: 130 - 134 - Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification(2010)
Authors: Piotr Zabrocki, Michaël Porcu, Jan Cools
Pages: 4353 - 4362 - FIP1L1-PDGFRA CAN CAUSE BOTH MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISEASE IN MOUSE BONE MARROW TRANSPLANT MODELS(2010)
Authors: Jan Cools
Pages: 165 - 165 - Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia(2010)
Authors: Ria Kleppe, Kim De Keersmaecker, Katrien Van Roosbroeck, Iwona Krajewska, Peter Vandenberghe, Jan Cools
Pages: 530 - 535 - Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia(2010)
Authors: Ria Kleppe, Kim De Keersmaecker, Katrien Van Roosbroeck, Peter Vandenberghe, Jan Cools
Pages: 530 - 535 - ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions(2010)
Authors: Katrien Van Roosbroeck, Jan Cools, Daan Dierickx, Peter Vandenberghe, Chris Peeters, Peter Marynen
Pages: 509 - 513 - Downstream effectors of FIP1L1-PDGFRA as targets for therapy in chronic eosinophilic leukemia(2010)
Authors: Els Lierman, R Snoeckx, E Stover, Nathalie Berghen, P Bulens, P Erben, A Reiter, Peter Vandenberghe, Jan Cools
Pages: 165 - 165 - Identification and characterization of novel oncogenes in chronic eosinophilic leukemia and T-cell acute lymphoblastic leukemia(2010)
Authors: Jan Cools
Pages: 55 - 70
Patents
1 - 2 of 2