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Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
1 - 10 of 62
- Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targetsFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- GAINING INSIGHT IN THE MUTATIONAL PROFILE OF PT-DLBCL AND ASSESSING ITS BIOLOGICAL EFFECTS AND TRANSFORMING POTENTIALFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Degradation of CDK1 and HDACs as a strategy to treat T-cell malignanciesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Uncovering mechanisms of TLX1/TLX3 oncogenic cooperation in leukemiaFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- EZH2 as a transcriptional activator in T-ALLFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- TLX transcriptional complexes in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Mechanisms of resistance to current treatment of acute myeloid leukemiaFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Oncogene cooperation enhancing TLX1 positive leukemia developmentFrom1 Sep 2022 → TodayFunding: Other federal public and semi-governmental institutions
Publications
21 - 30 of 200
- MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance(2021)
Authors: Jan Cools
Pages: 3394 - 3405 - BETter insight into PRC2-mutated T-ALL(2021)
Authors: Jan Cools
Pages: 1787 - 1788 - Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma(2021)
Authors: Sofie Demeyer, Jan Cools
Pages: 1040 - 1052 - 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia(2021)
Authors: Kim De Keersmaecker, Peter Vandenberghe, Stein Aerts, Jan Cools
Pages: 773 - 784 - Oncogenic Cooperation Between IL7R-JAK-STAT Pathway Mutations(2021)
Authors: Inge Lodewijckx, Jan Cools
- Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia(2021)
Authors: Quentin Van Thillo, Jolien De Bie, Sofie Demeyer, Heidi Segers, Nancy Boeckx, Anne Uyttebroeck, Jan Cools
- Genomics, Transcriptomics, and Minimal Residual Disease Detection: The Winning Team to Guide Treatment of Acute Lymphoblastic Leukemia(2021)
Authors: Heidi Segers, Jan Cools
Pages: 294 - 296 - PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia(2021)
Authors: Inge Govaerts, Charlien Vandersmissen, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
- Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified(2021)
Authors: Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Gregor Verhoef, Lucienne Michaux, Thomas Tousseyn, Jan Cools, Daan Dierickx
- The Fifth Year of HemaSphere(2021)
Authors: Jan Cools
Patents
1 - 2 of 2