Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
1 - 10 of 62
- Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targetsFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- GAINING INSIGHT IN THE MUTATIONAL PROFILE OF PT-DLBCL AND ASSESSING ITS BIOLOGICAL EFFECTS AND TRANSFORMING POTENTIALFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Degradation of CDK1 and HDACs as a strategy to treat T-cell malignanciesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Uncovering mechanisms of TLX1/TLX3 oncogenic cooperation in leukemiaFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- EZH2 as a transcriptional activator in T-ALLFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- TLX transcriptional complexes in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Mechanisms of resistance to current treatment of acute myeloid leukemiaFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Oncogene cooperation enhancing TLX1 positive leukemia developmentFrom1 Sep 2022 → TodayFunding: Other federal public and semi-governmental institutions
Publications
41 - 50 of 200
- PRC2 Mutaties in T-cel Acute Lymfatische Leukemie: Suz12 inactivatie coöpereert met JAK3 Mutant Signaling in T-cel Acute Lymfatische Leukemie(2019)
Authors: Michaël Broux, Jan Cools
- Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia(2019)
Authors: Michaël Broux, Cristina PRIETO FERNANDEZ, Sofie Demeyer, Marlies Vanden Bempt, Inge Lodewijckx, Roel Vandepoel, Jan Cools
Pages: 1323 - 1336 - Introducing the HemaSphere Controversies Series(2019)
Authors: Jan Cools
- Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells(2019)
Authors: Kim Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Benno Verbelen, Stijn Vereecke, Pieter Vermeersch, David Cassiman, Jan Cools, Mark Fiers, et al.
- Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition(2019)
Authors: Charles De Bock, Inge Lodewijckx, Delphine Verbeke, David Nittner, Sofie Demeyer, James Dooley, Adrian Liston, Jan Cools, Bart De Strooper
- Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia(2019)
Authors: Jan Cools
Pages: 2291 - 2304 - T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development(2019)
Authors: Charles De Bock, Mark Fiers, Jan Cools
Pages: E204 - E207 - The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL (vol 33, pg 319, 2019)(2019)
Authors: Kim Kampen, Sergey Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Laura Fancello, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, et al.
Pages: 1055 - 1055 - Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery(2019)
Authors: Peter Vandenberghe, Jan Cools
Pages: 712 - 725 - The First Year of HemaSphere and Many More to Come(2018)
Authors: Jan Cools
Patents
1 - 2 of 2