Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
11 - 20 of 62
- Cooperation between N-MYC overexpression and epiginetic deregulation in peripheral T cell lymphomaFrom1 Oct 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Viral Oncology: molecular biology and pathogenesis of post-transplant lymphoproliferative disorder (PTLD)From13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The TLX3 Transcriptional Complex in T-Cell Acute Lymphoblastic Leukemia.From20 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Extensive preclinical validation of combinations of targeted treatment for peripheral T cell lymphomaFrom10 Aug 2021 → 30 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- PSEN1-selective gamma-secretase inhibition for the treatment of T-cell acute lymphoblastic leukemiaFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- PSEN1-selective gamma-secretase inhibition for the treatment of T-cell acute lymphoblastic leukemia (T-ALL)From25 Aug 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Combining CRISPR screening and single-cell RNA sequencing to unravel the mechanisms of T-cell acute lymphoblastic leukemia.From1 Oct 2019 → 30 Sep 2023Funding: Foundations, funds and other with scientific goal
- Combining CRISPR screening and single-cell RNA sequencing to unravel the mechanisms of T-cell acute lymphoblastic leukemiaFrom1 Oct 2019 → TodayFunding: FWO fellowships, BOF - doctoral mandates
- Single cell sequencing analysis of acute lymphoblastic leukemia.From1 Jun 2019 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- Single-cell map of the composition and evolution of adult Acute Lympjoblastic Leukemia.From1 Jan 2019 → 30 Nov 2019Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 200
- Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome(2024)
Authors: Emilie Pollenus, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen Vanoirbeek, Greetje Vande Velde, Philippe Van den Steen
- Identification of novel targets for treatment in T-cell acute lymphoblastic leukemia(2023)
Authors: Inge Govaerts, Jan Cools
- CRISPR screening in hematology research: from bulk to single-cell level(2023)
Authors: Sarah Meyers, Sofie Demeyer, Jan Cools
- Combination therapy of a PSEN1-selective γ-secretase inhibitor with dexamethasone and an XPO1 inhibitor to target T-cell acute lymphoblastic leukemia(2023)
Authors: Charlien Vandersmissen, David Nittner, Johan Maertens, Heidi Segers, Jan Cools
Pages: 2507 - 2512 - Targeting STAT5B in T-cell acute lymphoblastic leukemia(2023)
Authors: Jan Cools
Pages: 215 - 217 - Primary mediastinal large B-cell lymphoma is hallmarked by large-scale copy-neutral loss of heterozygosity(2023)
Authors: Jonas Demeulemeester, Lucienne Michaux, Jan Cools, Thomas Tousseyn
Pages: 525 - 525 - Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer(2023)
Authors: Elien Heylen, Paulien Verstraete, Linde Van Aerschot, Tom Venken, David Nittner, Anne Uyttebroeck, Heidi Segers, Diether Lambrechts, Jan Cools, Kim De Keersmaecker, et al.
Pages: 1862 - 1878 - A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling(2023)
Authors: Ginevra Doglioni, Alex Cuadros, Xiaozheng Liu, dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Margherita Demicco, François Richard, Tatjana Geukens, Maxim De Schepper, et al.
Pages: 344 - + - Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma(2022)
Authors: Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, David Nittner, Thomas Tousseyn, Jan Cools, Daan Dierickx
Pages: 2463 - 2476 - Genetic drivers of peripheral T-cell lymphomagenesis(2022)
Authors: Koen Debackere, Daan Dierickx, Gregor Verhoef, Jan Cools
Patents
1 - 2 of 2