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Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → TodayFunding: BOF - projects, IOF - technology concept exploration
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → TodayFunding: FWO research project
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project
Publications
1 - 10 of 150
- Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death.(2022)
Authors: Geert Bultynck, Jean-Baptiste Parys
Pages: 102593 - A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors.(2022)
Authors: Martijn Kerkhofs, Geert Bultynck, Jean-Baptiste Parys
Pages: 119206 - TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence(2022)
Authors: Jean-Baptiste Parys
Number of pages: 18 - Preface to the Special Issue of the European Calcium Society in honor of Professor Sir Michael J. Berridge Preface(2021)
Authors: Jean-Baptiste Parys, Geert Bultynck
Number of pages: 3 - Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis(2021)
Authors: Nicolas Rosa, Nikolaos Louros, Spyridoula Karamanou, Frederic Rousseau, Joost Schymkowitz, Anastassios Economou, Jean-Baptiste Parys, Geert Bultynck
Pages: 788 - 805Number of pages: 18 - Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca2+ signaling(2021)
Authors: Jens Loncke, Tim Vervliet, Jean-Baptiste Parys, Geert Bultynck
Pages: 1 - 10 - Balancing ER-Mitochondrial Ca2+Fluxes in Health and Disease(2021)
Authors: Jens Loncke, Jean-Baptiste Parys, Martijn Kerkhofs, Geert Bultynck
Pages: 598 - 612Number of pages: 15 - A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels(2021)
Authors: Geert Bultynck, Jean-Baptiste Parys
Number of pages: 19 - Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(2021)
Authors: Patrizia Agostinis, Geert Bultynck, Abhishek Garg, Manosij Ghosh, Jan Gunst, Peter Hoet, Barjouhi Manshian, Ivan Nombela Diaz, Jean-Baptiste Parys, Stefaan Soenen, et al.
Pages: 1 - 382 - A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membrane(2021)
Authors: Bruno Seitaj, Geert Bultynck, Jean-Baptiste Parys