< Back to previous page
Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 160
- The interplay between associated proteins, redox state and Ca2+in the intraluminal ER compartment regulates the IP3 receptor(2024)
Authors: Jan Parys
- The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions(2023)
Authors: Geert Bultynck, Jan Parys
- Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit(2023)
Authors: Jan Parys, Geert Bultynck
- LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner(2023)
Authors: Rita La Rovere, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Jan Parys
- The ER-mitochondria interface, where Ca2+and cell death meet(2023)
Authors: Martijn Kerkhofs, Jens Loncke, Geert Bultynck, Jan Parys
- Modulation of Ca2+signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival(2022)
Authors: Nicolas Rosa, Jan Parys, Geert Bultynck
- Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease(2022)
Authors: Jan Parys
- TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy(2022)
Authors: Jan Parys, Geert Bultynck
- Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death(2022)
Authors: Geert Bultynck, Jan Parys
- Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis(2022)
Authors: Nicolas Rosa, Rita La Rovere, Nikolaos Louros, Lily Karamanou, Frederic Rousseau, Joost Schymkowitz, Tassos Economou, Jan Parys, Geert Bultynck
Pages: 788 - 805