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Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
21 - 30 of 160
- Insights In Bcl-2 Dependence In Diffuse Large B-Cell Lymphomas -Two Sides Of The Same Anti-Apoptotic Coin(2020)
Authors: Martijn Kerkhofs, Geert Bultynck, Jan Parys
- EPIC3, a novel Ca2+ indicator located at the cell cortex and in microridges, detects high Ca2+ subdomains during Ca2+ influx and phagocytosis(2020)
Authors: Tim Vervliet, Geert Bultynck, Jan Parys
- Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range(2020)
Authors: Jan Parys
- Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery(2020)
Authors: Bruno Seitaj, Rita La Rovere, Jan Parys, Geert Bultynck
- STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells(2020)
Authors: Jan Parys
- Necroptosis in Immuno-Oncology and Cancer Immunotherapy(2020)
Authors: Jenny Sprooten, Isaure Vanmeerbeek, Peter Vangheluwe, Susan Schlenner, Jan Parys, Geert Bultynck, Abhishek Garg
- Bcl-2-protein family as modulators of IP₃ receptors and other organellar Ca²⁺ channels(2020)
Authors: Hristina Ivanova, Tim Vervliet, Giovanni Monaco, Nicolas Rosa, Jan Parys, Geert Bultynck
- Type 3 IP3 receptors: The chameleon in cancer(2020)
Authors: Nicolas Rosa, Flore Sneyers, Jan Parys, Geert Bultynck
Pages: 101 - 148 - New Insights in the IP3 Receptor and Its Regulation(2020)
Authors: Jan Parys, Tim Vervliet
Pages: 243 - 270 - The role of intracellular Ca2+ dynamics in autophagy(2019)
Authors: Gemma Roest, Jan Parys, Geert Bultynck