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Researcher
Johan Swinnen
- Disciplines:Oncology, Medical systems biology
Affiliations
- Laboratory of Lipid Metabolism and Cancer (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Lipid Metabolism and Cancer (Division)
Member
From1 Jan 2012 → Today - Clinical and Experimental Endocrinology (Division)
Member
From1 Jan 2003 → 31 Dec 2011 - Department of Development and Regeneration (Department)
Member
From1 Oct 2000 → 31 Dec 2002
Infrastructure
1 - 2 of 2
- An high-throughput automated small molecule screening platform (Consortium coordinator)
- Next Generation Magnetic Resonance Mass Spectrometry. (Consortium coordinator)
Projects
11 - 20 of 51
- Exploiting acquired vulnerabilities in fatty acid metabolism to overcome therapy resistance in castration resistant prostate cancerFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Exploitation of lipid metabolism in improving cancer immune checkpoint therapy responseFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Lipometrix – towards an integrated lipidomics platform.From1 Nov 2020 → 31 Oct 2023Funding: BOF - research organisations
- Preclinical optimization of a novel combination approach exploiting a therapy-induced vulnerability to reactive oxygen species.From1 Sep 2019 → 31 Aug 2022Funding: Foundations, funds and other with scientific goal
- Association between different measures of global and local adiposity with clinico-pathological features, circulating markers, lipidomic profiles and outcome in postmenopausal breast cancer patients treated in the IBCSG 35-07 (SOLE) / BIG 1-07 trialFrom15 Jan 2019 → 14 Jan 2022Funding: Private funding of national origin - undefined
- Fatty acid metabolism as a novel adaptive response to high intratumoral pressure/temperature and promising target for the treatment of solid tumorsFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Steering tumors towards a ferroptosis-mediated immunogenic death by exploiting vulnerabilities in lipid metabolismFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- NOVEL THERAPY FOR BRAIN METASTASISFrom1 Oct 2018 → 18 Nov 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Refining cancer cell death and danger signals for the improvement of immunotherapyFrom1 Jan 2018 → 31 Dec 2021Funding: FWO EOS
Publications
1 - 10 of 133
- Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer(2024)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation regulates mitochondrial 13-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels(2024)
Authors: Johan Swinnen
- Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.(2024)
Authors: Yingli Zhu, Yoke Chin Chai, Patrizia Agostinis, Johan Swinnen
Pages: 6 - Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Targeting lipid metabolism to overcome therapy resistance in pancreatic cancer(2023)
Authors: Vincent de Laat, Johan Swinnen
- C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 1720 - 1747 - A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 666 - 679 - Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
Patents
1 - 5 of 5
- Screening methods for compounds modulating polyamine transport (Inventor)
- Combination treatment of arsenic oxide and antiandrogens (Inventor)
- Cancer phospholipidome (Inventor)
- CANCER PHOSPHOLIPIDOME (Inventor)
- PHOSPHOLIPID PROFILING OF CANCER (Inventor)