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Researcher
Johan Swinnen
- Disciplines:Oncology, Medical systems biology
Affiliations
- Laboratory of Lipid Metabolism and Cancer (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Lipid Metabolism and Cancer (Division)
Member
From1 Jan 2012 → Today - Clinical and Experimental Endocrinology (Division)
Member
From1 Jan 2003 → 31 Dec 2011 - Department of Development and Regeneration (Department)
Member
From1 Oct 2000 → 31 Dec 2002
Infrastructure
1 - 2 of 2
- An high-throughput automated small molecule screening platform (Consortium coordinator)
- Next Generation Magnetic Resonance Mass Spectrometry. (Consortium coordinator)
Projects
31 - 40 of 51
- Exploiting alterations in lipid metabolism to improve diagnosis, treatment and molecular imaging of prostate cancerFrom1 Jul 2015 → 31 Dec 2022Funding: Foreign Nonprofit organisations and equivalents
- Lipidomic alterations in prostate cancer as mediators and markers of androgen responses to androgen receptor antagonists.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Fatty acid elongation as a key mediator and target in the cancer-immunity axis.From1 Jan 2015 → 31 Dec 2016Funding: Foundations, funds and other with scientific goal
- Phospolipid profiling of lung cancer : identification of acyl chain elongation as a novel oncogenic event.From1 Oct 2014 → 31 Mar 2015Funding: Nonprofit institution or equivalents
- A microfluidics-based exosome analysis platform for the detection of residual and metastatic cancer cells.From1 Oct 2014 → 30 Sep 2019Funding: Private funding of national origin - undefined
- Nuclear-cytoplasmic transport as novel therapeutic target.From1 Oct 2014 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Lipid-mediated cilium loss in cancer cells as a novel driver of cellular autonomy and potential target for interventionFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Global exosomes biomarker.From1 Dec 2012 → 31 May 2015Funding: Foreign foundations, funds with scientific view
- Oncogene- and tumor growth-driven remodeling of phospholipid membranes as a platform to modulate cancer-related processes.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Proteomics and lipidomics of superparamagnetic nanoparticle (SPMNP)-isolated plasma membranes: a innovative strategy to identify novel targets/biomarkers in disease.From1 Jan 2011 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 133
- Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer(2024)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation regulates mitochondrial 13-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels(2024)
Authors: Johan Swinnen
- Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.(2024)
Authors: Yingli Zhu, Yoke Chin Chai, Patrizia Agostinis, Johan Swinnen
Pages: 6 - Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Targeting lipid metabolism to overcome therapy resistance in pancreatic cancer(2023)
Authors: Vincent de Laat, Johan Swinnen
- C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 1720 - 1747 - A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 666 - 679 - Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
Patents
1 - 5 of 5
- Screening methods for compounds modulating polyamine transport (Inventor)
- Combination treatment of arsenic oxide and antiandrogens (Inventor)
- Cancer phospholipidome (Inventor)
- CANCER PHOSPHOLIPIDOME (Inventor)
- PHOSPHOLIPID PROFILING OF CANCER (Inventor)