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Researcher
Johan Swinnen
- Disciplines:Oncology, Medical systems biology
Affiliations
- Laboratory of Lipid Metabolism and Cancer (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Lipid Metabolism and Cancer (Division)
Member
From1 Jan 2012 → Today - Clinical and Experimental Endocrinology (Division)
Member
From1 Jan 2003 → 31 Dec 2011 - Department of Development and Regeneration (Department)
Member
From1 Oct 2000 → 31 Dec 2002
Infrastructure
1 - 2 of 2
- An high-throughput automated small molecule screening platform (Consortium coordinator)
- Next Generation Magnetic Resonance Mass Spectrometry. (Consortium coordinator)
Projects
41 - 50 of 51
- The 'Lipogenic Switch' in cancer cells.From1 Dec 2010 → 5 Feb 2019Funding: IWT personal funding - strategic basic research grants
- Membrane changes in cancer cells: a biophysical and functional study.From1 Oct 2010 → 6 Jul 2017Funding: Nonprofit institution or equivalents, IWT personal funding - strategic basic research grants
- Lipid profiling of cancer tissue: possibilities for cancer subtyming and applications for diagnosis and therapy.From1 Oct 2010 → 23 Sep 2015Funding: IWT personal funding - strategic basic research grants
- The effects of the clinically applicable chemotherapeutics on the immunogenicity of melanoma cell death.From1 Oct 2010 → 31 Mar 2015Funding: Nonprofit institution or equivalents, BOF - Doctoral projects
- A state-of-the-art high speed live imaging confocal Nikon A1R.From22 Jul 2010 → 21 Jan 2017Funding: Hercules - Small and Medium size research infrastructure
- Study of pro-survival effects of increased lipogenesis in cancer cells: implications for carcinogenesis and therapy.From1 Oct 2009 → 18 Nov 2014Funding: FWO fellowships
- Implementation of functional imaging and molecular diagnostics for patient-tailored treatment of prostate cancer.From15 Sep 2009 → 30 Jun 2015Funding: Ministery of Social Affairs, Public Health and Environment
- Prognostic and therapeutic value of gene expression profiles in renal cancerFrom1 Aug 2009 → 31 May 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Implementation of functional imaging and molecular diagnostics for patient-tailored treatment of prostate cancer.From1 Jan 2009 → 30 Sep 2015Funding: Ministery of Social Affairs, Public Health and Environment
- Tumor-associated fatty acid synthase expression: impact on lipid composition and on functionality of membranes, role in cancer cell biology and applications for cancer intervention.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 133
- Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer(2024)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation regulates mitochondrial 13-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels(2024)
Authors: Johan Swinnen
- Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.(2024)
Authors: Yingli Zhu, Yoke Chin Chai, Patrizia Agostinis, Johan Swinnen
Pages: 6 - Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Targeting lipid metabolism to overcome therapy resistance in pancreatic cancer(2023)
Authors: Vincent de Laat, Johan Swinnen
- C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 1720 - 1747 - A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 666 - 679 - Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
Patents
1 - 5 of 5
- Screening methods for compounds modulating polyamine transport (Inventor)
- Combination treatment of arsenic oxide and antiandrogens (Inventor)
- Cancer phospholipidome (Inventor)
- CANCER PHOSPHOLIPIDOME (Inventor)
- PHOSPHOLIPID PROFILING OF CANCER (Inventor)