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Researcher
Johan Van Lint
- Disciplines:Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism, Morphological sciences, Oncology, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Laboratory of Protein Phosphorylation and Proteomics (Division)
Member
From1 Apr 2009 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2001 → 30 Sep 2005
Projects
1 - 10 of 13
- Structural, molecular, and cellular biology of PKD2 allosteric modulators as novel therapeutics for cancerFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- DIPITO: valorisation of deep immune profiling and novel immunotherapeutics for oncology.From1 Oct 2021 → TodayFunding: IOF - mandates
- PRISMO: Precision Medicine through Integrated Spatial Multi-OmicsFrom1 Feb 2020 → TodayFunding: Department Coordination
- Structural biology in aid of the design of next generation PKD2 inhibitorsFrom29 Aug 2019 → 29 Aug 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Clin-IC: Medtech solutions for patientsFrom1 May 2018 → TodayFunding: IOF - mandates, IOF - Industrial Research Fund
- Selective tyrosine phosphorylation of the PKD2 activation segment: a novel regulatory mechanism to achieve isoenzyme specific signaling within the protein kinase D family.From1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- A better understanding of Protein Kinase D structure and regulation serving the development of innovative anti-cancer kinase inhibitors.From1 Oct 2017 → 30 Sep 2022Funding: BOF - Concerted Research Project from 1994
- The role of the Protein Phosphatase 2A Activator PTPA in KRAS-mutant non-small-cell lung cancer development and treatment resistanceFrom1 Feb 2015 → 10 Nov 2021Funding: BOF - Doctoral projects
- Novel insights in the pharmacological inhibition and isoform-specific regulation of protein kinase D2.From1 Mar 2013 → 5 Jul 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- Characterization of Staphylococcus aureus primase DnaG, a potential antibacterial target.From1 Oct 2011 → 31 Dec 2015Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 27
- De rol van de Proteïne Fosfatase 2A Activator PTPA in KRAS-mutante niet-kleincellige longkankerontwikkeling en behandelingsresistentie(2021)
Authors: Bob Meeusen, Veerle Janssens, Johan Van Lint, Rita Derua
- LSA-50 paper: An alternative to P81 phosphocellulose paper for radiometric protein kinase assays(2021)
Authors: Olivia Appelmans, Wim De Borggraeve, Arnout Voet, Johan Van Lint
- Developments in the Discovery and Design of Protein Kinase D Inhibitors(2021)
Authors: Lauren Voets, Johan Van Lint, Wim De Borggraeve
Pages: 2158 - 2171 - Design, synthesis and biological evaluation of pyrazolo[3,4-d] pyrimidine-based protein kinase D inhibitors(2020)
Authors: Philippe Gilles, Rudra Shankar Kashyap, Steven De Jonghe, Dirk Daelemans, Johan Van Lint, Arnout Voet, Wim De Borggraeve
- Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation(2018)
Authors: Rita Derua, Etienne Waelkens, Veerle Janssens, Johan Van Lint
Pages: 2432 - 2443 - Protein kinase D2: a versatile player in cancer biology(2018)
Authors: Mathias Cobbaut, Johan Van Lint
Pages: 1263 - 1278 - Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms(2018)
Authors: Johan Van Lint
- Nieuwe inzichten in de farmacologische inhibitie en isovormspecifieke regulatie van Proteine Kinase D2(2017)
Authors: Mathias Cobbaut, Johan Van Lint, Rita Derua, Veerle Janssens
- Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling(2017)
Authors: Dries Bauters, Mathias Cobbaut, Lotte Geys, Johan Van Lint, Bianca Hemmeryckx, Roger Lijnen
Pages: 715 - 724 - Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop(2017)
Authors: Mathias Cobbaut, Rita Derua, Etienne Waelkens, Veerle Janssens, Johan Van Lint