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Researcher
John Creemers
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Biochemical Neuroendocrinology (Division)
Responsible
From1 Jan 2006 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 25
- Unraveling the pathology of the novel congenital myasthenic syndrome-22 (CMS22) and investigation of molecular links with Prader-Willi syndrome.From1 Oct 2021 → TodayFunding: FWO fellowships
- the role of Furin in colorectal cancerFrom1 Apr 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome; functional characterization and exploration of novel therapeutic avenues.From19 Aug 2019 → TodayFunding: Foundations, funds and other with scientific goal
- PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome; functional characterization and exploration of novel therapeutic avenuesFrom1 Jan 2019 → TodayFunding: FWO research project
- Therapeutic targeting of PC1/3 deficiency: from obesity to gastrointestinal disordersFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project
- Functional characterization of PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome, and evaluation of new medication for the treatment of myastheniaFrom1 Oct 2016 → 30 Sep 2020Funding: BOF - Concerted Research Project from 1994
- Repair and upgrade of the high resolution biological SEMFrom1 Oct 2016 → 30 Sep 2018Funding: BOF - Doctoral projects
- The role of the proprotein convertases in diabetes and obesityFrom1 Sep 2016 → 12 Jul 2022Funding: FWO fellowships
- The role of the proprotein convertase Furin in diabetes and obesity.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project
- Functional characterization of PREPL and the role in Prader-Willi syndromeFrom1 Jan 2015 → 13 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 88
- Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors(2022)
Authors: Johannes Creemers
- The proprotein convertase furin in cancer: more than an oncogene(2022)
Authors: Johannes Creemers
Pages: 1252 - 1262 - Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function(2021)
Authors: Natalia Gunko, Johannes Creemers
- In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23(2021)
Authors: Johannes Creemers
- Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic beta Cells of Mice(2021)
Authors: Ilaria Coppola, Johannes Creemers
- Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea(2021)
Authors: Laetitia Aerts, Johannes Creemers
- Spectrum of social alterations in the Neurobeachin haploinsufficiency mouse model of autism(2021)
Authors: Paulien Odent, Johannes Creemers, Guy Bosmans, Rudi D'Hooge
Pages: 11 - 21 - Loss of Furin in beta-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to beta-Cell Dysfunction(2021)
Authors: Ilaria Coppola, Natalia Gunko, Lieven Thorrez, Frans Schuit, Johannes Creemers
Pages: 492 - 503 - A Novel Aneurysm Gene: Whole Exome Sequencing of Abdominal Aortic Aneurysm Patients Unveils Impaired Tgf beta Signaling Related to the Proprotein Convertase Gene FURIN(2020)
Authors: Zongsheng He, Rosan Lechner, Arne S Ijpma, Robert M Hofstra, Hence J Verhagen, Henny T Bruggenwirth, Daphne Heijsman, Danny Huylebroeck, Johannes Creemers, Danielle Majoor-Krakauer
Pages: E273 - E273 - Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer(2020)
Authors: Johannes Creemers