< Back to previous page
Researcher
John Creemers
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Biochemical Neuroendocrinology (Division)
Responsible
From1 Jan 2006 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Unraveling the pathology of the novel congenital myasthenic syndrome-22 (CMS22) and investigation of molecular links with Prader-Willi syndrome.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- the role of Furin in colorectal cancerFrom1 Apr 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Exploring metabolic pathways that link Congenital Myasthenic Syndrome-22, caused by PREPL deficiency to Prader-Willi SyndromeFrom19 Aug 2019 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome; functional characterization and exploration of novel therapeutic avenuesFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Therapeutic targeting of PC1/3 deficiency: from obesity to gastrointestinal disordersFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Functional characterization of PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome, and evaluation of new medication for the treatment of myastheniaFrom1 Oct 2016 → 30 Sep 2020Funding: BOF - Concerted Research Project from 1994
- Repair and upgrade of the high resolution biological SEMFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- The role of the proprotein convertases in diabetes and obesityFrom1 Sep 2016 → 12 Jul 2022Funding: FWO fellowships
- Functional characterization of PREPL and the role in Prader-Willi syndromeFrom1 Jan 2015 → 13 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 91
- Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice(2021)
Authors: Ilaria Coppola, John Creemers
- Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea(2021)
Authors: Laetitia Aerts, John Creemers
- Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction(2021)
Authors: Ilaria Coppola, Lieven Thorrez, Frans Schuit, Jeroen Declercq, John Creemers
Pages: 492 - 503 - Spectrum of social alterations in the Neurobeachin haploinsufficiency mouse model of autism(2021)
Authors: Paulien Odent, John Creemers, Guy Bosmans, Rudi D'Hooge
Pages: 11 - 21 - A Novel Aneurysm Gene: Whole Exome Sequencing of Abdominal Aortic Aneurysm Patients Unveils Impaired Tgf beta Signaling Related to the Proprotein Convertase Gene FURIN(2020)
Authors: Zongsheng He, Rosan Lechner, Arne S Ijpma, Robert M Hofstra, Hence J Verhagen, Henny T Bruggenwirth, Daphne Heijsman, Danny Huylebroeck, John Creemers, Danielle Majoor-Krakauer
Pages: E273 - E273 - Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer(2020)
Authors: John Creemers
- The role of the proprotein convertase furin in cancer(2020)
Authors: Zongsheng He, John Creemers, Sabine Tejpar
- Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer(2020)
Authors: John Creemers
Pages: 40 - 49 - The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer(2020)
Authors: Lieven Thorrez, Sabine Tejpar, John Creemers
Pages: 3571 - 3587 - Post-weaning infant-to-mother bonding in nutritionally independent female mice(2020)
Authors: Stijn Stroobants, John Creemers, Guy Bosmans, Rudi D'Hooge