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Researcher
John Creemers
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Biochemical Neuroendocrinology (Division)
Responsible
From1 Jan 2006 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Unraveling the pathology of the novel congenital myasthenic syndrome-22 (CMS22) and investigation of molecular links with Prader-Willi syndrome.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- the role of Furin in colorectal cancerFrom1 Apr 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Exploring metabolic pathways that link Congenital Myasthenic Syndrome-22, caused by PREPL deficiency to Prader-Willi SyndromeFrom19 Aug 2019 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome; functional characterization and exploration of novel therapeutic avenuesFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Therapeutic targeting of PC1/3 deficiency: from obesity to gastrointestinal disordersFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Functional characterization of PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome, and evaluation of new medication for the treatment of myastheniaFrom1 Oct 2016 → 30 Sep 2020Funding: BOF - Concerted Research Project from 1994
- Repair and upgrade of the high resolution biological SEMFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- The role of the proprotein convertases in diabetes and obesityFrom1 Sep 2016 → 12 Jul 2022Funding: FWO fellowships
- Functional characterization of PREPL and the role in Prader-Willi syndromeFrom1 Jan 2015 → 13 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 91
- STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells(2018)
Authors: John Creemers
Pages: 2612 - 2623 - Regulation of FGF23 and Bone Mass by the Proprotein Convertase Furin(2018)
Authors: Omar Al Rifai, Rachid Essalmani, John Creemers, Nabil G Seidah, Mathieu Ferron
Pages: 80 - 80 - Transgenic Artifacts Caused by Passenger Human Growth Hormone(2018)
Authors: Frans Schuit, John Creemers
Pages: 670 - 674 - Hyperphagia and Obesity in Prader-Willi Syndrome: PCSK1 Deficiency and Beyond?(2018)
Authors: John Creemers
- Prodomain of Furin Promotes Phospholipid Transfer Protein Proteasomal Degradation in Hepatocytes(2018)
Authors: John Creemers
- PREPL deficiency: delineation of the phenotype and development of a functional blood assay(2018)
Authors: Luc Régal, John Creemers
Pages: 109 - 118 - Proprotein convertase furin regulates osteocalcin and bone endocrine function(2017)
Authors: John Creemers
Pages: 4104 - 4117 - Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines(2017)
Authors: Jeroen Declercq, Bruno Ramos Molina, Wim Annaert, John Creemers
Pages: 432 - 439 - Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism(2017)
Authors: John Creemers, Peter Kovacs
Pages: 295 - 305 - The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers(2016)
Authors: John Creemers