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Researcher
John Creemers
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Biochemical Neuroendocrinology (Division)
Responsible
From1 Jan 2006 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Unraveling the pathology of the novel congenital myasthenic syndrome-22 (CMS22) and investigation of molecular links with Prader-Willi syndrome.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- the role of Furin in colorectal cancerFrom1 Apr 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Exploring metabolic pathways that link Congenital Myasthenic Syndrome-22, caused by PREPL deficiency to Prader-Willi SyndromeFrom19 Aug 2019 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome; functional characterization and exploration of novel therapeutic avenuesFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Therapeutic targeting of PC1/3 deficiency: from obesity to gastrointestinal disordersFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Functional characterization of PREPL, a serine hydrolase deleted in patients with a Prader Willi-like syndrome, and evaluation of new medication for the treatment of myastheniaFrom1 Oct 2016 → 30 Sep 2020Funding: BOF - Concerted Research Project from 1994
- Repair and upgrade of the high resolution biological SEMFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- The role of the proprotein convertases in diabetes and obesityFrom1 Sep 2016 → 12 Jul 2022Funding: FWO fellowships
- Functional characterization of PREPL and the role in Prader-Willi syndromeFrom1 Jan 2015 → 13 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
81 - 90 of 91
- Bioactive peptides, networks and systems biology(2009)
Authors: Kurt Boonen, John Creemers, Liliane Schoofs
Pages: 300 - 314 - Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome(2009)
Authors: Gert Matthijs, John Creemers
Pages: bcr08.2008 - Mutations in the Amino-Terminal Region of Proopiomelanocortin (POMC) in Patients with Early-Onset Obesity Impair POMC Sorting to the Regulated Secretory Pathway(2008)
Authors: John Creemers
Pages: 4494 - 9 - Position effect leading to haploinsufficiency in a mosaic ring chromosome 14 in a boy with autism(2008)
Authors: Bernard Thienpont, Karolien Volders, An Crepel, Joris Vermeesch, Wim Van de Ven, Jean Steyaert, John Creemers, Koenraad Devriendt
Pages: 1187 - 1192 - T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance(2008)
Authors: Anton Roebroek, John Creemers
Pages: 246 - 250 - Multi-system disorder syndromes associated with cystinuria type I(2008)
Authors: Gert Matthijs, John Creemers
Pages: 544 - 550 - Delayed PLAG1-induced tumorigenesis in a conditional fur knockout mouse model: an incentive for a search for furin inhibitors(2008)
Authors: Wim Van de Ven, Fons Vermorken, John Creemers
- Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate(2008)
Authors: Anton Roebroek, Roel Quintens, Frans Schuit, Wim Van de Ven, John Creemers
Pages: 12319 - 12324 - Common nonsynonymous variants in PCSK1 confer risk of obesity(2008)
Authors: John Creemers
Pages: 943 - 5 - MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice(2008)
Authors: Jeroen Declercq, Boudewijn Van Damme, Anton Roebroek, Fons Vermorken, Jan Ceuppens, Wim Van de Ven, John Creemers
Pages: 1073 - 1083