Researcher
Joost Schymkowitz
- Keywords:Applied biological sciences, biotechnology
- Disciplines:(Bio)medical engineering
Affiliations
- Department of Bio-engineering Sciences (Department)
Member
From1 Apr 2004 → 31 Mar 2010 - Cellular Processes governed by protein conformational changes (Research group)
Member
From1 Sep 2003 → 31 Mar 2010
Projects
1 - 2 of 2
- Structural and biophysiscal characterisation of toxic oligomers of the Alzheimer’s beta peptideFrom1 Jan 2009 → 31 Dec 2012Funding: FWO research project (including WEAVE projects)
- An analysis of the effects of Alzheimer’s disease-associated risk factors on the toxicity of Aß aggregationFrom1 Jan 2009 → 31 Dec 2013Funding: FWO Odysseus
Publications
1 - 10 of 40
- EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation(2023)
Authors: Adekunle T Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F Gallego, Nils Schoovaerts, Spyridoula Karamanou, Nikolaos Louros, Ella Martin, et al.
Pages: 1402-1422.e13 - Liquid-Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation(2021)
Authors: Donya Pakravan, Emiel Michiels, Anna Bratek-Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost Schymkowitz, Frederic Rousseau, et al.
- Structural Basis of the Subcellular Topology Landscape of Escherichia coli(2019)
Authors: Maria S Loos, Reshmi Ramakrishnan, Wim Vranken, Alexandra Tsirigotaki, Evrydiki-Pandora Tsare, Valentina Zorzini, Jozefien De Geyter, Biao Yuan, Ioannis Tsamardinos, Maria Klappa, et al.
Pages: 1-22 - Loss of DPP6 in neurodegenerative dementia(2019)
Authors: Rita Cacace, Bavo Heeman, Sara Van Mossevelde, Arne De Roeck, Julie Hoogmartens, Peter De Rijk, Helena Gossye, Kristof De Vos, Wouter De Coster, Mojca Strazisar, et al.
Pages: 901-918 - Frizzled 7 and PIP2 binding by syntenin PDZ2 domain controls Frizzled 7 trafficking and signaling.(2016)
Authors: Antonio Egea-Jimenez, Rodrigo Gallardo, Abel Garcia-Pino, Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Remy Loris, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann
- From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors(2016)
Authors: Ana Zafra Ruano, Elisa Cilia, José R Couceiro, Javier Ruiz Sanz, Joost Schymkowitz, Frederic Rousseau, Irene Luque, Tom Lenaerts
- Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool(2012)
Authors: Annelies Vandersteen, Marcelo F Masman, Greet De Baets, Wim Jonckheere, Kees Van Der Werf, Siewert J. Marrink, Jef Rozenski, Iryna Benilova, Bart Destrooper, Vinod Subramaniam, et al.
Pages: 36732-36743 - α-Galactosidase Aggregation Is a Determinant of Pharmacological Chaperone Efficacy on Fabry Disease Mutants(2012)
Authors: Aleksandra Siekierska, Greet De Baets, Joke Reumers, Rodrigo Gallardo Tapia, Stanislav Rudyak, Kerensa Broersen, Couceiro Jose, Joost Van Durme, Joost Schymkowitz, Frederic Rousseau
Pages: 28386-28397 - Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness(2012)
Authors: Jacinte Beerten, Wim Jonckheere, Stanislav Rudyak, Jie Xu, Hannah Wilkinson, Frederik De Smet, Joost Schymkowitz, Frederic Rousseau
Pages: 357-366 - Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease(2012)
Authors: K. Pauwels, Tl Williams, Kl Morris, Wim Jonckheere, Annelies Vandersteen, G. Kelly, Joost Schymkowitz, Frederic Rousseau, Annalisa Pastore, Louise Serpell, et al.
Pages: 5650-5660
Patents
1 - 8 of 8
- Methods for screening inhibitors of tumour associated protein aggregation. (Inventor)
- Molecules and methods for inhibition and detection of proteins (Inventor)
- Means and methods for mediating protein interference
- Methods for screening inhibitors of tumor associated protein aggregation
- Targeted induction of aggregation of proteins with cross beta structures (Inventor)
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor (Inventor)
- Molecules and methods for inhibition and detection of proteins
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor