Researcher
Joost Schymkowitz
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Proteins, Bioinformatics of disease, Structural bioinformatics and computational proteomics, Synthetic biology, Proteomics
- See also: Joost Schymkowitz (Flanders Institute for Biotechnology)
Affiliations
- Switch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From15 Sep 2010 → 31 Dec 2010
Infrastructure
1 - 1 of 1
- When size matters: a platform to study molecular interactions and multimerisation (Consortium coordinator)
Projects
11 - 20 of 54
- Assessing co-translational protein aggregation and the cellular factors that prevent itFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting radionuclides to tumors expressing extracellular Hsp90 using rationally designed peptide probesFrom22 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Charge preference of the Mammalian protein quality control machineryFrom19 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the role of tau aggregates in neurodegenerationFrom15 Feb 2021 → TodayFunding: FWO fellowships
- Deciphering Tau structure and oligomerization propensities: Towards innovative therapeutics, prognostics and diagnosticsFrom1 Jan 2021 → 31 Dec 2023Funding: IOF - technology validation in lab
- Mapping the proteostatic collapse caused by aggregation-inducing bactericidal peptidesFrom1 Nov 2020 → TodayFunding: FWO senior postdoctoral fellowship
- A comprehensive model for protein aggregation and its application to the design of monoclonal antibodies and peptides for targeted aggregationFrom1 Oct 2020 → 30 Sep 2021Funding: BOF - postdoctoral mandates
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
Publications
1 - 10 of 159
- Integrating physics in deep learning algorithms: a force field as a PyTorch module.(2024)
Authors: Gabriele Orlando, Joost Schymkowitz, Frederic Rousseau
Pages: btae160 - Local structural preferences in shaping tau amyloid polymorphism(2024)
Authors: Grigoria Tsaka, Rodrigo Gallardo, Dietmar Thal, Frederic Rousseau, Joost Schymkowitz
- N-glycosylation as a eukaryotic protective mechanism against protein aggregation.(2024)
Authors: Bert Houben, Matthias De Vleeschouwer, Matthew Wilson, Gert Matthijs, Joost Schymkowitz, Frederic Rousseau
Pages: eadk8173 - Modulation of hen egg white protein techno-functionality by amyloid formation(2024)
Authors: Anja Vananroye, Paula Moldenaers, Joost Schymkowitz, Frederic Rousseau, Jan Delcour
- LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons(2023)
Authors: Sofie Beckers, Katerina Konstantoulea, Maarten Dewilde, Frederic Rousseau, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
- Mechanisms and pathology of protein misfolding and aggregation(2023)
Authors: Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
Pages: 912 - 933 - Improved coalescence and creaming stability of structured oil-in-water emulsions and emulsion gels containing ovalbumin amyloid-like fibrils produced by heat and enzymatic treatments(2023)
Authors: Frederic Rousseau, Joost Schymkowitz, Jan Delcour
- TDP‑43 pathology is associated with increased tau burdens and seeding(2023)
Authors: Sandra Oliveira Tomé, Grigoria Tsaka, Klara Gawor, Philip Van Damme, Ludo Van Den Bosch, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Thal
- Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding(2023)
Authors: Laleh Khodaparast, Ladan Khodaparast, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Frederic Rousseau, Joost Schymkowitz
- Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium(2023)
Authors: Ignace Vergote, Toon Van Gorp, Frederic Rousseau, Joost Schymkowitz
Pages: 2473 - 2484
Patents
1 - 10 of 10
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Beta-lactamase inhibitors (Inventor)
- Carbon dioxide generation (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Means and methods for the prediction of amyloid core sequences (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting ras protein (Inventor)
- Carbon dioxide generation (Inventor)