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Researcher

Josephina Meester

  • Research Expertise:I am currently doing research in the field of skeletal dysplasia and thoracic aortic aneurysm and dissection. These two groups of diseases are related in the context of disease causing mutations in the gene BGN. My comprehensive study contributes to the elucidation of the pathomechanisms and, hence, treatment of biglycan related disease. In order to achieve this goal, I use iPSC-derived cell (chondrocytes and vascular smooth muscle cells) and mouse models. In addition, I also make use of large genomic datasets of patients with thoracic aortic aneurysms to identify novel genetic causes for this disease.
  • Keywords:GENETICS, CARDIOVASCULAR, Medicine
  • Disciplines:Cardiac and vascular medicine, Laboratory medicine, Molecular and cell biology
  • Research techniques:Next-generation sequecing, functional assays, mouse models, echocardiography, induced pluripotent stem cells, vascular smooth muscle cells, chondrocytes.
  • Users of research expertise:Other researchers