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Researcher
Kalyan Das
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2017 → Today
Projects
1 - 10 of 10
- Structural study and integrative modelling of the yeast Sin3/Rpd3 histone deacetylase complexesFrom7 Oct 2022 → TodayFunding: FWO fellowships
- High-resolution cryo-EM structures of the human and yeast Sin3 histone deacetylase complexesFrom1 Oct 2022 → TodayFunding: HORIZON.1.2 - Marie Skłodowska-Curie-actions (MSCA)
- Structure-based drug design targeting Nipah virus RNA polymeraseFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural snapshots of transcription initiation process by human and yeast mitochondrial RNA polymerases.From1 Sep 2020 → TodayFunding: FWO fellowships
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Structure-based design of ribonucleoside triphosphate (rNTP) analogs targeting bacterial RNA polymerasesFrom16 Oct 2018 → 30 Sep 2020Funding: BOF - Other initiatives
- Structure-based design of ribonucleoside triphosphate (rNTP) analogs targeting bacterial RNA polymerasesFrom1 Oct 2018 → 30 Sep 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Structure-based design and synthesis of nucleoside-triphosphate analogs as new classes of viral polymerase inhibitorsFrom25 Sep 2017 → 10 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 38
- Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.(2023)
Authors: Eva Pauwels, Neesha Rajesh Shewakramani, Piet Maes, Kurt Vermeire, Kalyan Das
- Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine(2022)
Authors: Abhi Singh, Dominique Schols, Piet Herdewyn, Christophe Pannecouque, Kalyan Das
- Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies(2022)
Authors: Abhi Singh, Kalyan Das
- A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals(2022)
Authors: Julien Olivet, Kalyan Das
Pages: 1797 - 1800 - Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening(2021)
Authors: Abhi Singh, Kalyan Das
- Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design(2021)
Authors: Weijie Gu, Sergio Martinez, Abhi Singh, Jef Rozenski, Dominique Schols, Piet Herdewyn, Kalyan Das, Steven De Jonghe
- Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.(2021)
Authors: Abhi Singh, Kalyan Das
Pages: 7127 - HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites(2021)
Authors: Kalyan Das
Pages: 16530 - 16540 - Structure-based design and synthesis of nucleoside-triphosphate analogs as new classes of viral polymerase inhibitors(2021)
Authors: Weijie Gu, Kalyan Das, Piet Herdewyn, Steven De Jonghe
- Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)(2021)
Authors: Kalyan Das