Researcher
Kim De Keersmaecker
- Disciplines:Cancer biology
Affiliations
- Laboratory for Disease Mechanisms in Cancer (Division)
Responsible
From1 Oct 2016 → Today - Laboratory for Disease Mechanisms in Cancer (Division)
Member
From1 Oct 2014 → Today - Department of Human Genetics (Department)
Member
From1 Oct 2013 → 30 Sep 2014 - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Mar 2009 → 30 Sep 2015
Projects
1 - 10 of 42
- Raising the voice of silent mutations in cancerFrom1 Oct 2023 → TodayFunding: BOF - postdoctoral mandates
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom4 Jul 2021 → TodayFunding: FWO fellowships
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- VyCAP single cell isolation platform for high-quality single-cell analysisFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Role of -1 programmed ribosomal frameshifting dysregulation on the JAK2 oncogeneFrom25 Jul 2020 → TodayFunding: FWO fellowships
- Silent mutations in cancerFrom1 May 2020 → TodayFunding: H2020 - Frontier Research (ERC)
- The role of NKX2-1 in T-cell acute lymphoblastic leukemia and NKX2-1 cooperation with the ribosomal RPL10 R98S and NOTCH1 mutations.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Role of PTEN dysregulation downstream of ribosomal protein RPL5/RPL11 lesions in cancer.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Fidelity of translation in healthy agingFrom26 Sep 2019 → 26 Sep 2023Funding: BOF - doctoral mandates
Publications
11 - 20 of 89
- Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells.(2022)
Authors: Benno Verbelen, Kim De Keersmaecker
Number of pages: 15 - Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells(2022)
Authors: Benno Verbelen, Paulien Verstraete, Sonia Cinque, Maya Imbrechts, Nick Geukens, Daniele Pepe, Kim Kampen, Kim De Keersmaecker
Pages: 100 - 114 - How Ribosomal Protein Mutations Translate Cancer(2021)
Authors: Stijn Vereecke, Kim De Keersmaecker
- 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia(2021)
Authors: Kim De Keersmaecker, Peter Vandenberghe, Stein Aerts, Jan Cools
Pages: 773 - 784 - PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia(2021)
Authors: Inge Govaerts, Charlien Vandersmissen, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
- Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia(2021)
Authors: Sofie Demeyer, Inge Govaerts, Jolien De Bie, Lucienne Michaux, Johan Maertens, Anne Uyttebroeck, Kim De Keersmaecker, Nancy Boeckx, Heidi Segers, Jan Cools
Pages: 801 - 811 - The ins and outs of serine and glycine metabolism in cancer(2021)
Authors: Elien Heylen, Kim De Keersmaecker, Kim Kampen
Pages: 131 - 141 - Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth(2021)
Authors: Shauni Geeraerts, Kim Kampen, Gianmarco Rinaldi, Purvi Gupta, Nikolaos Louros, Elien Heylen, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, et al.
Pages: 50 - 63 - Metabolic rewiring in cancer: Pharmacological targeting of serine/glycine synthesis addicted cancers(2020)
Authors: Shauni Geeraerts, Kim De Keersmaecker, Bruno Cammue, Karin Thevissen, Kim Kampen
- Codon bias analyses on thyroid carcinoma genes(2020)
Authors: Daniele Pepe, Kim De Keersmaecker
Pages: 295 - 305
Patents
1 - 3 of 3