Researcher
Kim De Keersmaecker
- Disciplines:Cancer biology
Affiliations
- Laboratory for Disease Mechanisms in Cancer (Division)
Responsible
From1 Oct 2016 → Today - Laboratory for Disease Mechanisms in Cancer (Division)
Member
From1 Oct 2014 → Today - Department of Human Genetics (Department)
Member
From1 Oct 2013 → 30 Sep 2014 - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Mar 2009 → 30 Sep 2015
Projects
1 - 10 of 42
- Raising the voice of silent mutations in cancerFrom1 Oct 2023 → TodayFunding: BOF - postdoctoral mandates
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom4 Jul 2021 → TodayFunding: FWO fellowships
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- VyCAP single cell isolation platform for high-quality single-cell analysisFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Role of -1 programmed ribosomal frameshifting dysregulation on the JAK2 oncogeneFrom25 Jul 2020 → TodayFunding: FWO fellowships
- Silent mutations in cancerFrom1 May 2020 → TodayFunding: H2020 - Frontier Research (ERC)
- The role of NKX2-1 in T-cell acute lymphoblastic leukemia and NKX2-1 cooperation with the ribosomal RPL10 R98S and NOTCH1 mutations.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Role of PTEN dysregulation downstream of ribosomal protein RPL5/RPL11 lesions in cancer.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Fidelity of translation in healthy agingFrom26 Sep 2019 → 26 Sep 2023Funding: BOF - doctoral mandates
Publications
21 - 30 of 89
- The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia(2020)
Authors: Delphine Verbeke, Sofie Demeyer, Jolien De Bie, Anne Uyttebroeck, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools
Pages: 5747 - 5758 - SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP(2020)
Authors: Kim De Keersmaecker
- Hallmarks of ribosomopathies(2020)
Authors: Kim Kampen, Stijn Vereecke, Kim De Keersmaecker
Pages: 1013 - 1028 - Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation(2020)
Authors: Nicolas Kint, Elien Heylen, Daniele Pepe, Kim De Keersmaecker, Catherine Verfaillie, Michel Delforge
Pages: 651 - 655 - Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1(+) Leukemia (vol 19, pg 740, 2011)(2020)
Authors: Thomas Schmidt, Behzad Kharabi Masouleh, Sonja Loges, Sandra Cauwenberghs, Peter Fraisl, Christa Maes, Bart Jonckx, Kim De Keersmaecker, Maria Kleppe, Marc Tjwa, et al.
Pages: 135 - 136 - Ruxolitinib Synergizes With Dexamethasone for the Treatment of T-cell Acute Lymphoblastic Leukemia(2019)
Authors: Delphine Verbeke, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, Jan Cools
- In search of novel working mechanisms of proteasome inhibitors in multiple myeloma(2019)
Authors: Nicolas Kint, Michel Delforge, Catherine Verfaillie, Kim De Keersmaecker
- Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells(2019)
Authors: Kim Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Benno Verbelen, Stijn Vereecke, Pieter Vermeersch, David Cassiman, Jan Cools, Mark Fiers, et al.
- The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL (vol 33, pg 319, 2019)(2019)
Authors: Kim Kampen, Sergey Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Laura Fancello, Gianmarco Rinaldi, Jelle Verbeeck, Joyce Op de Beeck, Anne Uyttebroeck, et al.
Pages: 1055 - 1055 - Cancer Biogenesis in Ribosomopathies(2019)
Authors: Kim Kampen, Kim De Keersmaecker
Patents
1 - 3 of 3