Researcher
Kris Vleminckx
- Keywords:cancer research, rare diseases, CRISPR/Cas9, Developmental biology
- Disciplines:Cell signalling, Developmental genetics, Genome structure and regulation, Developmental biology, Vertebrate biology, Epigenetics, Genetics, Animal developmental and reproductive biology, Cancer biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 2013 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1999 → Today
Projects
1 - 10 of 30
- Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney diseaseFrom1 Nov 2023 → TodayFunding: BOF - postdoctoral mandates
- Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formationFrom1 Nov 2023 → TodayFunding: FWO fellowships
- CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferenciated liposarcomaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cellsFrom1 Oct 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalisFrom1 May 2022 → 30 Apr 2023Funding: BOF - doctoral mandates
- Investigating the role and mechanism of EZH2 in immune checkpoint resistance in tumors with Wnt/ß-catenin pathway activationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Identification et caractérisation des facteurs de dépendance dans un modèle génétique de tumeur desmoïde de Xenopus tropicalisFrom1 Sep 2020 → 31 Aug 2022Funding: Other international institutions, not mentioned elsewhere
- Precision medicine in inherited blindness using integrated omics in human and animal modelsFrom1 Jan 2020 → TodayFunding: BOF - projects
- Identifying and characterizing dependency factors in a genetic Xenopus tropicalis desmoid tumor modelFrom15 Jul 2019 → 14 Jul 2021Funding: Foreign foundations, funds with scientific view
- CRISPR/Cas9-based in vivo identification of EZH2 as a therapeutic target in desmoid tumors and small cell lung cancerFrom1 Jan 2019 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 62
- Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis(2023)
Authors: Dieter Tulkens, Marthe Boelens, Thomas Naert, Marjolein Carron, Suzan Demuynck, Sylviane Dewaele, Gert Van Isterdael, David Creytens, Tim Pieters, Steven Goossens, et al.
Pages: 2404 - 2413 - Engraftment of allotransplanted tumor cells in adult rag2 mutant Xenopus tropicalis(2022)
Authors: Dieter Tulkens, Dionysia Dimitrakopoulou, Marthe Boelens, Tom Van Nieuwenhuysen, Suzan Demuynck, Wendy Toussaint, Pieter Van Vlierberghe, Kris Vleminckx
- CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping(2021)
Authors: Thomas Naert, Dieter Tulkens, Tom Van Nieuwenhuysen, Joanna Przybyl, Suzan Demuynck, Matt van de Rijn, Mushriq Al-Jazrawe, Benjamin A. Alman, Paul Coucke, Kim De Leeneer, et al.
- RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis(2020)
Authors: Thomas Naert, Dionysia Dimitrakopoulou, Dieter Tulkens, Suzan Demuynck, Rivka Noelanders, Liza Eeckhout, Gert Van Isterdael, Dieter Deforce, Christian Vanhove, Kris Vleminckx
Pages: 2692 - 2706 - Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis(2019)Volume: 27
Authors: D. Dimitrakopoulou, T. Naert, D. Tulkens, R. Noelanders, T. Van Nieuwenhuyse, Pieter Van Vlierberghe, Kris Vleminckx
Pages: 863 - 863 - Modeling human hereditary cancer syndromes using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis(2019)Volume: 27
Authors: D. Dimitrakopoulou, T. Naert, D. Tulkens, R. Noelanders, T. Van Nieuwenhuyse, Pieter Van Vlierberghe, Kris Vleminckx
Pages: 475 - 475 - ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia(2019)
Authors: Maximilian Haas, Jose Luis Gomez Vazquez, Dingyuan Iris Sun, Hong Tran Thi, Magdalena Brislinger, Alexia Tasca, Orr Shomroni, Kris Vleminckx, Peter Walentek
Pages: 3338 - 3352 - A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus(2019)
Authors: Jiejing Li, Mark Perfetto, Christopher Materna, Rebecca Li, Hong Tran Thi, Kris Vleminckx, Melinda K. Duncan, Shuo Wei
- Xenopus tropicalis : joining the armada in the fight against blood cancer(2019)
Authors: Dionysia Dimitrakopoulou, Dieter Tulkens, Pieter Van Vlierberghe, Kris Vleminckx
- CRISPR/Cas9-mediated knockout of Rb1 in Xenopus tropicalis(2018)Series: Methods in Molecular Biology
Authors: Thomas Naert, Kris Vleminckx, Pedro G Santiago-Cardona
Pages: 177 - 193