Researcher
Kris Vleminckx
- Keywords:cancer research, rare diseases, CRISPR/Cas9, Developmental biology
- Disciplines:Cell signalling, Developmental genetics, Genome structure and regulation, Developmental biology, Vertebrate biology, Epigenetics, Genetics, Animal developmental and reproductive biology, Cancer biology
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 2013 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1999 → Today
Projects
1 - 10 of 30
- Morphological, molecular and functional insights into the cardiovascular complications of autosomal dominant polycystic kidney diseaseFrom1 Nov 2023 → TodayFunding: BOF - postdoctoral mandates
- Interspecies exploration of the (post)transcriptional and epigenomic signatures associated with Wilms' tumor formationFrom1 Nov 2023 → TodayFunding: FWO fellowships
- CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferenciated liposarcomaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Pathomechanistic study of RCBTB1-associated inherited retinal disease using Xenopus tropicalis and patient-derived induced pluripotent stem cellsFrom1 Oct 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- Functional assessment of cis-regulatory elements of inherited retinal diseases (IRDs) in Xenopus tropicalisFrom1 May 2022 → 30 Apr 2023Funding: BOF - doctoral mandates
- Investigating the role and mechanism of EZH2 in immune checkpoint resistance in tumors with Wnt/ß-catenin pathway activationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Identification et caractérisation des facteurs de dépendance dans un modèle génétique de tumeur desmoïde de Xenopus tropicalisFrom1 Sep 2020 → 31 Aug 2022Funding: Other international institutions, not mentioned elsewhere
- Precision medicine in inherited blindness using integrated omics in human and animal modelsFrom1 Jan 2020 → TodayFunding: BOF - projects
- Identifying and characterizing dependency factors in a genetic Xenopus tropicalis desmoid tumor modelFrom15 Jul 2019 → 14 Jul 2021Funding: Foreign foundations, funds with scientific view
- CRISPR/Cas9-based in vivo identification of EZH2 as a therapeutic target in desmoid tumors and small cell lung cancerFrom1 Jan 2019 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
Publications
41 - 50 of 62
- CRISPR/Cas9 disease models in zebrafish and Xenopus : the genetic renaissance of fish and frogs
Authors: Thomas Naert, Kris Vleminckx
Pages: 41 - 52 - Homozygous null TBX4 mutations lead to posterior amelia with pelvic and pulmonary hypoplasia
Authors: Ariana Kariminejad, Emmanuelle Szenker-Ravi, Caroline Lekszas, Homa Tajsharghi, Ali-Reza Moslemi, Thomas Naert, Hong Tran Thi, Fatemeh Ahangari, Minoo Rajaei, Mojila Nasseri, et al.
Pages: 1294 - 1301 - Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis
Authors: Warif El Yakoubi, Caroline Borday, Johanna Hamdache, Karine Parain, Hong Tran Thi, Kris Vleminckx, Muriel Perron, Morgane Locker
Pages: 2784 - 2795 - Wnt/U+03B2-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo
Authors: Hong Tran Thi, Belaid Sekkali, Griet Van Imschoot, Sylvie Janssens, Kris Vleminckx
Pages: 16160 - 16165 - The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation
Authors: Sylvie Janssens, Olaf van den Broek, Ian R Davenport, Robbert C Akkers, Fei Liu, Gert Jan C Veenstra, Stefan Hoppler, Kris Vleminckx, Olivier Destrée
Pages: 49 - 54 - Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos
Authors: Belaïd Sekkali, Hong Tran Thi, Ellen Crabbe, Christophe De Beule, Frans Van Roy, Kris Vleminckx
Pages: 2534 - 2540 - Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4
Authors: Jian Song, Xueming Liu, Jiada Li, Huadie Liu, Zhen Peng, Yalan Liu, Lingyun Mei, Chufeng He, Xinzhang Cai, Hongsheng Chen, et al.
Pages: 6631 - 6639 - SF3B2, a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein
Authors: Caroline Van Cauwenbergh, Kris Vleminckx, Marcus Karlstetter, Thomas Langmann, Gael Manes, Christian P Hamel, Elfride De Baere
Number of pages: 1 - CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal diseaseVolume: 59
Authors: Giulia Ascari, Thomas Naert, Tom Van Nieuwenhuysen, Suzan Demuynck, Chris Guerin, Kris Vleminckx
Number of pages: 1 - You'd better catch that Wnt-primitive hematopoiesis requires canonical Wnt signaling
Authors: Hong Tran Thi, Kris Vleminckx
Pages: 366 - 367