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- Research interest:Kristel Sleegers, MD PhD, is an expert in the complex genetics of Alzheimer's disease. With a background in medicine and genetic epidemiology she combines state-of-the-art molecular genetics techniques with statistical genetics to identify causal mutations, susceptibility alleles, genetic modifiers as well as genotype-phenotype correlations in a range of biomaterials, to elucidate the molecular underpinnings of Alzheimer's disease and related disorders, and to identify targets for improved disease management.
- Keywords:NEURODEGENERATIVE BRAIN DISEASES, MOLECULAR GENETICS, GENETIC EPIDEMIOLOGY, Biomedical sciences (incl. biochemistry)
- Disciplines:Genetics, Systems biology, Laboratory medicine, Molecular and cell biology, Neurosciences, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other clinical sciences, Public health care, Public health sciences, Public health services, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- Research techniques:Genetic EpidemiologyStatistical Genetics
- Users of research expertise:Researchers in molecular or medical genetics aiming to investigate complex genetic phenomena (e.g. rare variant association analysis on NGS data, genetic modifiers, genetic anticipation, polygenic risk, ...)Researchers performing in vitro or in vivo analysis, e.g. characterization of mutations, needing advice on statistical data analysis (e.g. non-parametric tests, linear mixed models, repeated measurements)