Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
11 - 20 of 73
- Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy(2019)
Authors: Tom Vanden Berghe, Yves Adriaenssens, Peter Vandenabeele, Koen Augustyns, Steven Staelens, Sigrid Stroobants, Pieter Van Der Veken, Leonie Wyffels
Pages: 4801 - 4824 - $^{18}F$-HX4 hypoxia PET holds promise as a prognostic and predictive imaging biomarker in a lung cancer xenograft model treated with metformin and radiotherapy(2019)
Authors: Sven De Bruycker, Christel Vangestel, Tim Van den Wyngaert, Patrick Pauwels, Leonie Wyffels, Steven Staelens, Sigrid Stroobants
Pages: 34 - 40 - Validation and noninvasive kinetic modeling of $[^{11}C]$UCB-J PET imaging in mice(2019)
Authors: Jeroen Verhaeghe, Alan Miranda Menchaca, Istvan Kertesz, Klaudia Cybulska, Spela Korat, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Longbin Liu, et al.
- Improved stability of a novel fluorine-18 labeled TCO analogue for pretargeted PET imaging(2019)
Authors: Eduardo Ruivo, Karuna Adhikari, Filipe Elvas, Jens Fissers, Christel Vangestel, Steven Staelens, Sigrid Stroobants, Pieter Van Der Veken, Leonie Wyffels, Koen Augustyns
Pages: 36 - 42 - Molecular imaging of $mGluR_{5}$ availability with [$^{11}C$]ABP68 in glutaminase heterozygous mice(2019)
Authors: Lauren Kosten, Steven Deleye, Sigrid Stroobants, Leonie Wyffels, Susana Mingote, Stephen Rayport, Steven Staelens
Pages: 255 - 263 - In vitro and In vivo assessment of suitable reference region and kinetic modelling for the mGluR1 radioligand $\left[^{11}C\right]$ITDM in mice(2019)
Authors: Jeroen Verhaeghe, Spela Korat, Alan Miranda Menchaca, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Longbin Liu, Mette Skinbjerg, Ignacio Munoz-Sanjuan, et al.
- Effects of metformin on tumor hypoxia and radiotherapy efficacy: a$[^{18}F]$HX4 PET imaging study in colorectal cancer xenografts(2019)
Authors: Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie Wyffels, Jan Detrez, Marlies Verschuuren, Winnok De Vos, Patrick Pauwels, Tim Van den Wyngaert, Sigrid Stroobants
- $^{18}$ F-FDG PET, the early phases and the delivery rate of $^{18}$ F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease(2019)
Authors: Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Ellen De Roeck, Leonie Wyffels, Sarah Ceyssens, Christine Van Broeckhoven, Sebastiaan Engelborghs, Sigrid Stroobants, Steven Staelens
Pages: 1172 - 1182 - State-associated changes in longitudinal $\left[^{18}F\right]$-PBR111 TSPO PET Imaging of psychosis patients(2019)
Authors: Livia De Picker, Julie Ottoy, Jeroen Verhaeghe, Steven Deleye, Leonie Wyffels, Erik Fransen, Lauren Kosten, Bernard Sabbe, Violette Coppens, Maarten Timmers, et al.
Pages: 46 - 54 - Noninvasive relative quantification of $\left[^{11}C\right]$ABP688 PET imaging in mice versus an input function measured over an arteriovenous shunt(2018)
Authors: Jeroen Verhaeghe, Lauren Kosten, David Thomae, Marleen Verhoye, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens