Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
21 - 30 of 73
- Neuroimaging of subacute brain inflammation and microstructural changes predicts long-term functional outcome after experimental traumatic brain injury(2018)
Authors: Stephan Missault, Cynthia Anckaerts, Ines Blockx, Steven Deleye, Debby Van Dam, Nora Barriche, Glenn De Pauw, Stephanie Aertgeerts, Femke Valkenburg, Jeroen Verhaeghe, et al.
- Acute ketamine infusion in rat does not affect in vivo $[^{11}C]$ABP688 binding to metabotropic glutamate receptor subtype 5(2018)
Authors: Lauren Kosten, Jeroen Verhaeghe, Leonie Wyffels, Sigrid Stroobants, Steven Staelens
- Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using $^{99m}Tc-duramycin$ during TNF-induced SIRS(2018)
Authors: Tinneke Delvaeye, Leonie Wyffels, Steven Deleye, Kelly Lemeire, Amanda Gonçalves, Elke Decrock, Steven Staelens, Luc Leybaert, Peter Vandenabeele, Dmitri Krysko
Pages: 1140 - 1145 - Longitudinal characterization of mGluR5 using $^{11}C$-ABP688 PET imaging in the Q175 mouse model of Huntington's disease(2018)
Authors: Lauren Kosten, Jeroen Verhaeghe, David Thomae, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
Pages: 1722 - 1727 - $^{18}F-PBR111$ PET imaging in healthy controls and schizophrenia(2018)
Authors: Julie Ottoy, Livia De Picker, Jeroen Verhaeghe, Steven Deleye, Leonie Wyffels, Lauren Kosten, Violette Coppens, Maarten Timmers, Luc Van Nueten, Sarah Ceyssens, et al.
Pages: 1267 - 1274 - Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-positron emission tomography imaging(2018)
Authors: Thomas De Vijlder, Jens Fissers, Bianca Van Broeck, Leonie Wyffels, Marc Mercken, Darrel J. Pemberton
Pages: 1643 - 1650 - $\left[^{99m}Tc\right]$duramycin for cell death imaging(2018)
Authors: Luca Palmieri, Christel Vangestel, Koon Pak, Brian Gray, Sigrid Stroobants, Steven Staelens, Leonie Wyffels
Pages: 1 - 9 - Non-invasive PET imaging of brain inflammation at disease onset predicts spontaneous recurrent seizures and reflects comorbidities(2017)
Authors: Daniele Bertoglio, Jeroen Verhaeghe, Eva Santermans, Halima Amhaoul, Elisabeth Jonckers, Leonie Wyffels, Niel Hens, Steven Staelens, Stefanie Dedeurwaerdere
Pages: 69 - 79 - MicroPET outperforms beta-microprobes in determining neuroreceptor availability under pharmacological restriction for cold mass occupancy(2017)
Authors: Dorien Glorie, Stijn Servaes, Jeroen Verhaeghe, Tine Wyckhuys, Leonie Wyffels, Olivier Vanderveken, Sigrid Stroobants, Steven Staelens
- Evaluation of [$^{18}F$]CP18 as a substrate-based apoptosis imaging agent for the assessment of early treatment response in oncology(2017)
Authors: Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, Tim Van den Wyngaert, Leonie Wyffels, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
Pages: 560 - 569