Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
41 - 50 of 73
- Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction(2016)
Authors: Lauren Kosten, Jeroen Verhaeghe, Robert Verkerk, David Thomae, Livia De Picker, Leonie Wyffels, Annemie Van Eetveldt, Stefanie Dedeurwaerdere, Sigrid Stroobants, Steven Staelens
Pages: 1 - 11 - Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting(2016)
Authors: Agnese Maggi, Eduardo Ruivo, Jens Fissers, Christel Vangestel, Sneha Chatterjee, Jurgen Joossens, Frank Sobott, Steven Staelens, Sigrid Stroobants, Pieter Van Der Veken, et al.
Pages: 7544 - 7551 - In vivo amyloid-$\beta$ imaging in the APPPS1-21 transgenic mouse model with a 89Zr- labeled monoclonal antibody(2016)
Authors: Ann-Marie Waldron, Jens Fissers, Annemie Van Eetveldt, Bianca Van Broeck, Marc Mercken, Darrel J. Pemberton, Pieter Van Der Veken, Koen Augustyns, Jurgen Joossens, Sigrid Stroobants, et al.
Pages: 1 - 12 - Synthesis and evaluation of a Zr-89-labeled monoclonal antibody for immuno-PET imaging of amyloid-$\beta$ deposition in the brain(2016)
Authors: Jens Fissers, Ann-Marie Waldron, Thomas De Vijlder, Bianca Van Broeck, Darrel J. Pemberton, Marc Mercken, Pieter Van Der Veken, Jurgen Joossens, Koen Augustyns, Stefanie Dedeurwaerdere, et al.
Pages: 598 - 605 - Early prediction of tumor response to treatment(2016)
Authors: Christel Vangestel, Koon Pak, Peter Vermeulen, Brian Gray, Sigrid Stroobants, Steven Staelens, Leonie Wyffels
Pages: 805 - 811 - $\mu PET$ imaging of the pharmacokinetic behavior of medium and high molar mass $^{89}Zr$-labeled poly(2-ethyl-2-oxazoline) in comparison to poly(ethylene glycol)(2016)
Authors: Leonie Wyffels, Thomas Verbrugghen, Bryn D. Monnery, Mathias Glassner, Sigrid Stroobants, Richard Hoogenboom, Steven Staelens
Pages: 63 - 71 - Baseline $[^{18}F]FMISO$ $\mu PET$ as a predictive biomarker for response to $HIF-1\alpha$ inhibition combined with 5-FU chemotherapy in a human colorectal cancer xenograft model(2016)
Authors: Sven De Bruycker, Christel Vangestel, Tim Van den Wyngaert, Leonie Wyffels, An Wouters, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
Pages: 606 - 616 - Quantitative $\mu PET$ imaging of cerebral glucose metabolism and amyloidosis in the TASTPM double transgenic mouse model of Alzheimer's disease(2015)
Authors: Ann-Marie Waldron, Leonie Wyffels, Jeroen Verhaeghe, Astrid Bottelbergs, Jill Richardson, Jonathan Kelley, Mark Schmidt, Sigrid Stroobants, Xavier Langlois, Steven Staelens
Pages: 694 - 703 - Characterization of $[^{99m}Tc]$duramycin as a SPECT imaging agent for early assessment of tumor apoptosis(2015)
Authors: Christel Vangestel, Sara Rapic, Jeroen Verhaeghe, Brian Gray, Koon Pak, Sigrid Stroobants, Steven Staelens, Leonie Wyffels
Pages: 838 - 847 - Rat brain normalization templates for robust regional analysis of [$^{11}C$]ABP688 positron emission tomography/computed tomography(2015)
Authors: Jeroen Verhaeghe, Leonie Wyffels, Tine Wyckhuys, Sigrid Stroobants, Steven Staelens