Researcher
Lieve Naesens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 15
- Inhibition of lung inflammation in pneumonia induced by micro-organismsFrom1 Mar 2023 → TodayFunding: IOF - technology validation in lab
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Designing airway-targeted prodrug strategies for anti-respiratory virus therapeuticsFrom12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Hitting coronavirus replication in its core by combined inhibition of the nsp12 polymerase and associated proteins of the replication-transcription complexFrom13 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Covalent locking of the influenza virus hemagglutinin prefusion structure: an innovative concept to create broadly protective influenza vaccinesFrom7 Sep 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Entry inhibitors for human respiratory virus SARS-CoV-2.From21 Aug 2017 → 6 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Automated real-time quantitative live cell analysisFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Characterization of the influenza virus polymerase using T-705 and ribavirin and design of RNA chain terminating prodrugs of these unique antiviral agentsFrom1 Jan 2015 → 31 Dec 2017Funding: FWO research grant KAN
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
Publications
11 - 20 of 179
- Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria(2022)
Authors: Lieve Naesens
- Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease(2022)
Authors: Annelies Stevaert, Els Vanstreels, Manon Laporte, Lieve Naesens
- A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro(2022)
Authors: Annelies Stevaert, Benjamin Van Loy, Lieve Naesens
- Synthesis and structure-activity relationship of L-methionine-coupled 1,3,4-thiadiazole derivatives with activity against influenza virus(2022)
Authors: Evelien Vanderlinden, Lieve Naesens
Pages: 398 - 415 - Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide(2022)
Authors: Annelies Stevaert, Sam Noppen, Lieve Naesens
- Overcome Double Trouble: Baloxavir Marboxil Suppresses Influenza Thereby Mitigating Secondary Invasive Pulmonary Aspergillosis(2022)
Authors: Laura Seldeslachts, Birger Tielemans, Eliane Vanhoffelen, Stephanie Humblet-Baron, Lieve Naesens, Katrien Lagrou, Erik Verbeken, Joost Wauters, Greetje Vande Velde
- A broad influenza virus inhibitor acting via IMP dehydrogenase and in synergism with ribavirin(2021)
Authors: Evelien Vanderlinden, Lieve Naesens
- Exploration of the 2,3-dihydroisoindole pharmacophore for inhibition of the influenza virus PA endonuclease(2021)
Authors: Lieve Naesens, Annelies Stevaert
- Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model(2021)
Authors: Laura Seldeslachts, Lore Vanderbeke, Agustin Reséndiz Sharpe, Tessa Ostyn, Lieve Naesens, Stephanie Humblet-Baron, Erik Verbeken, Katrien Lagrou, Joost Wauters, Greetje Vande Velde
Pages: 2493 - 2508 - Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1, 3-thiazolidin-4-one sulfonyl derivatives(2021)
Authors: Lieve Naesens