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Researcher
Lieve Naesens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 15
- Inhibition of lung inflammation in pneumonia induced by micro-organismsFrom1 Mar 2023 → TodayFunding: IOF - technology validation in lab
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Designing airway-targeted prodrug strategies for anti-respiratory virus therapeuticsFrom12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Hitting coronavirus replication in its core by combined inhibition of the nsp12 polymerase and associated proteins of the replication-transcription complexFrom13 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Covalent locking of the influenza virus hemagglutinin prefusion structure: an innovative concept to create broadly protective influenza vaccinesFrom7 Sep 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Entry inhibitors for human respiratory virus SARS-CoV-2.From21 Aug 2017 → 6 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Automated real-time quantitative live cell analysisFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Characterization of the influenza virus polymerase using T-705 and ribavirin and design of RNA chain terminating prodrugs of these unique antiviral agentsFrom1 Jan 2015 → 31 Dec 2017Funding: FWO research grant KAN
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
Publications
31 - 40 of 179
- Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin(2020)
Authors: Lieve Naesens
Pages: 1661 - 1671 - Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity(2020)
Authors: Lieve Naesens, Annelies Stevaert
- N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction(2020)
Authors: Evelien Vanderlinden, Manon Laporte, Annelies Stevaert, Lieve Naesens
- Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90(2020)
Authors: Lieve Naesens
- Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease(2020)
Authors: Steven De Jonghe, Dirk Daelemans, Lieve Naesens
Pages: 3610 - 3633 - Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses(2020)
Authors: Lieve Naesens
- Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors(2020)
Authors: Lieve Naesens
- Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents(2020)
Authors: Lieve Naesens
- Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways(2020)
Authors: Manon Laporte, Annelies Stevaert, Mohammed Benkheil, Bart Vanaudenaerde, Lieve Naesens
- Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones(2020)
Authors: Evelien Vanderlinden, Lieve Naesens