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Researcher
Mathy Froeyen
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Member
From1 Oct 2010 → 30 Sep 2011 - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Jul 2001 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Jun 2001
Projects
1 - 10 of 11
- Molecular modelling tools to design artificial enzymesFrom18 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → 30 Apr 2024Funding: FWO Medium Size Research Infrastructure
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Exploring the Sequence and Functional Landscapes of Natural and Engineered PolymerasesFrom8 Oct 2018 → TodayFunding: FWO fellowships
- Drug design strategies against newly emerging viral diseasesFrom17 Oct 2016 → 30 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Investigations on base pairing between N8-glycosylated 8-aza-guanine bases and 8-substituted purine bases.From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Development of XNA ligases as tools for synthetic biologyFrom22 Sep 2015 → 17 Oct 2019Funding: BOF - doctoral mandates, BOF - Doctoral projects
- Development of a xenozyme and an XNA ligase.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Rational Design of XNA Processing EnzymesFrom22 Sep 2014 → 6 Oct 2020Funding: BOF - Doctoral projects
- Synthesis of modified nucleotides for application in medicine and biotechnology.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 114
- Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline(2024)
Authors: Jérôme Rihon, Charles-Alexandre Mattelaer, Mathy Froeyen, Vitor Bernardes Pinheiro, Eveline Lescrinier
Pages: 2836 - 2847 - The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach(2022)
Authors: Steven De Jonghe, Dominique Schols, Mathy Froeyen
- New isolate from Salvinia molesta with antioxidant and urease inhibitory activity(2021)
Authors: Mathy Froeyen
Pages: 1169 - 1181 - Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species(2021)
Authors: Mathy Froeyen, Pieter Leyssen, Leen Delang, Johan Neyts
- Structure and folding of XNA aptamers studied by computational and experimental methods(2021)
Authors: Charles-Alexandre Mattelaer, Eveline Lescrinier, Mathy Froeyen
- Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro(2021)
Authors: Muhammad Usman Mirza, Mathy Froeyen
Pages: 4936 - 4948 - Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach (vol 155, 105537, 2020)(2021)
Authors: Muhammad Usman Mirza, Atefeh Saadabadi, Michiel Vanmeert, Outi MH Salo-Ahen, Iskandar Abdullah, Sandra Claes, Steven De Jonghe, Dominique Schols, Sarfraz Ahmad, Mathy Froeyen
- Efficient and Accurate Potential Energy Surfaces of Puckering in Sugar-Modified Nucleosides(2021)
Authors: Charles-Alexandre Mattelaer, Jérôme Rihon, Mathy Froeyen, Eveline Lescrinier
Pages: 3814 - 3823 - Toxicity Evaluation of the Naphthalen-2-yl 3,5-Dinitrobenzoate: A Drug Candidate for Alzheimer Disease(2021)
Authors: Mathy Froeyen
- Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b] pyridines as highly potent inhibitors of cyclin G-associated kinase(2021)
Authors: Mathy Froeyen, Dominique Schols, Piet Herdewyn, Steven De Jonghe