Researcher
Olivier Vanakker
- Keywords:paediatric genetics, soft tissue mineralisation, syndromology, molecular genetics, pathophysiological mechanisms, calcification diseases, pseudoxanthoma elasticum, clinical genetics, dysmorphology, ectopic mineralisation diseases, stroke, cerebrovascular diseases
- Disciplines:Paediatrics and neonatology not elsewhere classified, Clinical genetics and molecular diagnostics, Neonatology, Epigenetics, Immunogenetics, Paediatrics, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2003 → 30 Sep 2018
Projects
1 - 9 of 9
- International thematic network INTEC (ectopic calcifiaction)From1 Jan 2023 → TodayFunding: BOF - mobility
- Study of DDR/PARP1 signaling in the pathogenesis and treatment of soft tissue mineralization, using pseudoxanthoma elasticum as a model.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- An integrated translational platform to improve the management and outcome of rare heritable connective tissue diseaseFrom1 Jan 2021 → TodayFunding: BOF - projects
- Identifying mechanisms of disease variability in soft tissue mineralization disorders, using pseudoxanthoma elasticum as a modelFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model.From1 Nov 2020 → 30 Sep 2023Funding: FWO fellowships
- Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model.From1 Oct 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- An integrated approach towards understanding and treating soft tissue mineralization, with pseudoxanthoma elasticum as a model.From1 Jan 2015 → 31 Oct 2019Funding: BOF - Doctoral projects
- Unraveling the ophthalmological phenotype and etiopathogenetic mechanisms in pseudoxanthoma elasticumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships, BOF - Other initiatives
- Study of the cardiovascular phenotype and etiopathogenetic mechanisms in pseudoxanthoma elasticum.From1 Oct 2013 → TodayFunding: FWO fellowships
Publications
11 - 20 of 120
- Clinical and subclinical findings in heterozygous ABCC6 carriers : results from a Belgian cohort and clinical practice guidelines(2022)
Authors: Lukas Nollet, Laurence Campens, Julie De Zaeytijd, Dimitri Hemelsoet, Olivier Vanakker
Pages: 496 - 504 - The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization(2022)
Authors: Lukas Nollet, Olivier Vanakker
Pages: 10 - 10 - Mitochondrial dysfunction and oxidative stress in hereditary ectopic calcification diseases(2022)
Authors: Lukas Nollet, Olivier Vanakker
- Minocycline counteracts ectopic calcification in a murine model of pseudoxanthoma elasticum : a proof-of-concept study(2022)
Authors: Elise Bouderlique, Lukas Nollet, Emmanuel Letavernier, Olivier Vanakker
- Attenuation of dysfunctional DNA damage response and PARP1 signaling by minocycline reduces ectopic calcification in pseudoxanthoma elasticum(2022)Volume: 30
Authors: Lukas Nollet, Olivier Vanakker
Pages: 74 - 74 - Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice(2021)
Authors: Bettina Ibold, Janina Tiemann, Isabel Faust, Uta Ceglarek, Jullia Dittrich, Theo Gorgels, Arthur Bergen, Olivier Vanakker, Matthias Van Gils, Cornelius Knabbe, et al.
- Phenotypes and genotypes in non‐consanguineous and consanguineous primary microcephaly : high incidence of epilepsy(2021)
Authors: Sarah Duerinckx, Julie Désir, Camille Perazzolo, Cindy Badoer, Valérie Jacquemin, Julie Soblet, Isabelle Maystadt, Yusuf Tunca, Bettina Blaumeiser, Berten Ceulemans, et al.
- Rare modifier variants alter the severity of cardiovascular disease in pseudoxanthoma elasticum : identification of novel candidate modifier genes and disease pathways through mixture of effects analysis(2021)
Authors: Eva De Vilder, Ludovic Martin, Georges Lefthériotis, Paul Coucke, Filip Van Nieuwerburgh, Olivier Vanakker
- Comprehensive validation of a diagnostic strategy for sequencing genes with one or multiple pseudogenes using pseudoxanthoma elasticum as a model(2021)
Authors: Wouter Steyaert, Olivier Vanakker
Pages: 289 - 299 - Genotype-phenotype correlation in pseudoxanthoma elasticum(2021)
Authors: Jonas W. Bartstra, Sara Risseeuw, Pim A. de Jong, Bram van Os, Lianne Kalsbeek, Chris Mol, Annette F. Baas, Olivier Vanakker, Ralph J. Florijn, Jeroen Hendrikse, et al.
Pages: 18 - 26