Researcher
Patrick Pauwels
- Research Expertise:molecular oncopathology
- Keywords:ANATOMOPATHOLOGY, ONCOLOGY, Medicine
- Disciplines:Oncology not elsewhere classified
- Research techniques:Next gen seq, ddPCR, liquid and tissue biopsy NGS, immunohistochemie, FISH, organoids
- Users of research expertise:researchers in de field of oncology
Affiliations
- Center for Oncological Research (CORE) (Research group)
Member
From1 Jan 2019 → Today - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Oct 2009 → 31 Dec 2018
Projects
11 - 20 of 32
- Combined targeting of the epidermal growth factor receptor and the innate immune system: a novel therapeutic approach for the treatment of head and neck cancer.From1 Jan 2019 → 31 Dec 2023Funding: Nonprofit institution or equivalents
- Developing a novel synergistic approach of chemotherapy and immunotherapy to enhance the anti-tumor immune response in non-small cell lung cancer.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Analysis of plasma, platelets and urine nucleic acids: the value of liquid biopsy to improve diagnosis, follow-up and monitoring of treatment response of lung cancer and pancreatic cancer patients.From1 Sep 2017 → 31 Aug 2021Funding: Nonprofit institution or equivalents
- Will the CD70/CD27 pathway pave the way as target for immunotherapy in colorectal cancer?From1 Jan 2017 → 30 Jun 2017Funding: Nonprofit institution or equivalents
- Translational research on the novel combination of chemotherapy and anti-CD70 immunotherapy to improve treatment outcome in non-small cell lung cancer.From1 Oct 2016 → 31 Mar 2022Funding: Nonprofit institution or equivalents
- Investigation of DFNA5 as potential biomarker and tumour suppressor gene in 4 solid tumour types.From1 Oct 2016 → 30 Sep 2019Funding: FWO fellowships
- Identifying rational combination therapies to overcome intrinsic and acquired resistance to EGFR-targeting agents.From1 Oct 2016 → 31 Mar 2023Funding: Nonprofit institution or equivalents
- Predicting immunotherapy response in elderly non-small cell lung cancer patients by zooming into protein/peptide expression patterns at the tumor cell - immune cell interaction border.From1 Jan 2016 → 31 Dec 2019Funding: FWO Humanitarian research project Stand up against Cancer, VITO (Flemish Institute for Technological Research)
- Programmed death-1 as novel immunotherapeutic target in malignant pleural mesothelioma : investigation of cancer drug of the year 2013.From1 Jan 2015 → 31 Dec 2016Funding: Foundations, funds and other with scientific goal
- Early detection of response and relapse in patients with lung cancer using liquid biopsies.From1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 248
- Small airways disease in pre-COPD with emphysema(2024)
Authors: Stijn Verleden, Jeroen Hendriks, Annemiek Snoeckx, Cindy Mai, Yves Mentens, Wim Callebaut, Bruno De Belie, Paul Van Schil, Veronique Verplancke, Joe Jacob, et al.
Pages: 683 - 692 - Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition(2024)
Authors: Sabine Paternot, Eric Raspe, Clement Meiller, Maxime Tarabichi, Jean-Baptiste Assie, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, et al.
Pages: 866 - 894 - IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts(2024)
Authors: Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, et al.
Pages: 1 - 19 - Urine biomarkers in cancer detection(2023)
Authors: Stephanie Jordaens, Karen Zwaenepoel, Wiebren Tjalma, Christophe Deben, Koen Beyers, Vanessa Vankerckhoven, Patrick Pauwels, Alex Vorsters
Pages: 2186 - 2205 - Targeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer(2023)
Authors: Tal Flieswasser, Astrid Van den Eynde, Laurie Freire Boullosa, Jöran Melis, Christophe Hermans, Céline Merlin, Ho Wa Lau, Jonas Van Audenaerde, Filip Lardon, Evelien Smits, et al.
Pages: 1 - 11 - PD-1, PD-L1, IDO, CD70 and microsatellite instability as potential targets to prevent immune evasion in sarcomas(2023)
Authors: Vasiliki Siozopoulou, Evelien Smits, Karen Zwaenepoel, Jimmy Liu, Abraham Pouliakis, Patrick Pauwels, Elly Marcq
Pages: 1257 - 1273 - Protein biomarker discovery studies on urinary sEV fractions separated with UF-SEC for the first diagnosis and detection of recurrence in bladder cancer patients(2023)
Authors: Stephanie Jordaens, Eline Oeyen, Hanny Willems, Filip Ameye, Stefan De Wachter, Patrick Pauwels, Inge Mertens
Pages: 1 - 26 - Urine as a liquid biopsy for cancer detection(2023)
Authors: Stephanie Jordaens, Patrick Pauwels, Wiebren Tjalma, Alex Vorsters, Vanessa Vankerckhoven, Christophe Deben, Karen Zwaenepoel, Peter Van Dam, Stefan De Wachter
Number of pages: 265 - Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs(2023)
Authors: Katleen Janssens, Isabelle Neefs, Joe Ibrahim, Anne Schepers, Patrick Pauwels, Marc Peeters, Guy Van Camp, Ken Op de Beeck
Pages: 1 - 14 - Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe(2023)
Authors: P. Hofman, F. Calabrese, I. Kern, J. Adam, A. Alarcao, I. Alborelli, N.T. Anton, A. Arndt, A. Avdalyan, M. Barberis, et al.
Pages: 1 - 11
Patents
1 - 4 of 4
- Immunotherapy markers (Inventor)
- Cell-based therapeutics targeting CD70 (Inventor)
- Immunotherapy markers (Inventor)
- Immunotherapy Markers (Inventor)