Researcher
Roosmarijn Vandenbroucke
- Keywords (Ghent University):extracellular vesicles, gut inflammation, blood-brain barrier, neuroinflammation, aging, brain targeting
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Cell signalling, Inflammation, Innate immunity, Membrane structure and transport, Gastro-enterology, Infectious diseases, Neurosciences not elsewhere classified, Microbiome
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2022 → Today - Vandenbroucke Lab (Research group)
Responsible
From1 Mar 2018 → Today - Libert Lab (Research group)
Member
From1 Jan 2017 → 28 Feb 2018 - Department of Pharmaceutics (Department)
Member
From1 Jan 2003 → 30 Sep 2008 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 2001 → Today
Projects
11 - 20 of 24
- Field-flow fractionation (FFF) system for combination with high-end ICP-mass spectrometry (ICP-MS).From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- Replacement and extension of basic infrastructure in the histology core facility.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- Unravelling the role of the complement pathway and extracellular vesicles at the blood-cerebrospinal fluid interface in Alzheimer’s disease.From1 Nov 2020 → TodayFunding: FWO fellowships
- Design and pre-clincial evaluation of self-replicating mRNA therapeutics that produce protein drugs under control of small, non-toxic moleculesFrom1 Nov 2020 → TodayFunding: FWO fellowships
- High-precision isotopic analysis of essential metals as a novel tool for unraveling their role in Alzheimer's disease and for diagnostic/prognostic purposesFrom1 Nov 2020 → TodayFunding: FWO fellowships
- Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciencesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- High-precision isotopic analysis of essential metals as a novel tool for unraveling their role in Alzheimer's disease and for diagnostic/prognostic purposesFrom15 Nov 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- Holistic and temporal analysis of gut-brain communication during chronic gut inflammationFrom15 Nov 2019 → 30 Sep 2022Funding: BOF - doctoral mandates
- Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Unraveling the choroid plexus heterogeneity and its consequences on the biological response to inflammation.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
Publications
1 - 10 of 34
- Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease(2024)
Authors: Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito, Maude Jans, Fleur Boone, Charysse Vandendriessche, Ine Paesmans, Herve Maurin, Roosmarijn Vandenbroucke, et al.
- An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology(2024)
Authors: Lien Van Hoecke, Jonas Castelein, Junhua Xie, Lore Van Acker, Griet Van Imschoot, Elien Van Wonterghem, Ine Vlaeminck, Daan Verhaege, Wouter Claeys, Keimpe Wierda, et al.
Pages: 122 - 134 - Bacterial extracellular vesicles : an emerging avenue to tackle diseases(2023)
Authors: Junhua Xie, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn Vandenbroucke
Pages: 1206 - 1224 - Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology(2023)
Authors: Junhua Xie, Arnout Bruggeman, Clint De Nolf, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Lars Vereecke, Roosmarijn Vandenbroucke
- Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia(2023)
Authors: Yael Hirschberg, Natalia Valle-Tamayo, Oriol Dols-Icardo, Sebastiaan Engelborghs, Bart Buelens, Roosmarijn Vandenbroucke, Yannick Vermeiren, Kurt Boonen, Inge Mertens
- Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes(2023)
Authors: Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste, et al.
- Alzheimer's disease and age-related changes in the Cu isotopic composition of blood plasma and brain tissues of the APP^(NL-G-F) murine model revealed by multi-collector ICP-mass spectrometry(2023)
Authors: Kasper Hobin, Marta Costas Rodriguez, Elien Van Wonterghem, Roosmarijn Vandenbroucke, Frank Vanhaecke
- Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics(2022)
Authors: Marie Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, et al.
- Characterising extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC(2022)
Authors: Yael Hirschberg, Kurt Boonen, Karin Schildermans, Annemieke van Dam, Isabel Pintelon, Charysse Vandendriessche, Milica Velimirovic Fanfani, An Jacobs, Roosmarijn Vandenbroucke, Inge Nelissen, et al.
- Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus(2022)
Authors: Elien Van Wonterghem, Lien Van Hoecke, Griet Van Imschoot, Daan Verhaege, Marlies Burgelman, Roosmarijn Vandenbroucke