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Researcher
Sandrine Da Cruz
- Disciplines:Neurological and neuromuscular diseases
Affiliations
- Laboratory of Neurophysiology in Neurodegenerative Disorders (VIB- KU Leuven) (Lab)
Responsible
From1 Jan 2020 → Today - Laboratory of Neurophysiology in Neurodegenerative Disorders (VIB- KU Leuven) (Lab)
Member
From1 Jan 2020 → Today
Projects
1 - 8 of 8
- Studying the role of Integrated Stress Response in Amyotrophic Lateral Sclerosis (ALS)From21 Feb 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding vulnerability in ALS using multi-omicsFrom27 Jun 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Elucidating mechanisms underlying aggregation/spreading of RNA binding proteins in neurodegenerationFrom1 Sep 2021 → 27 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dissecting the role of ALS-causing RNA binding protein FUS in axonal local translationFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- ALS-fellowship – Elucidating the role of local translation in FUS-mediated amyotrophic lateral sclerosis (ALS)From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Identifying determinants of TDP-43 demixing/aggregation to axonal dysfunction in amyotrophic lateral sclerosis (ALS)From1 Oct 2020 → 30 Sep 2022Funding: BOF - projects
- Dystonia-associated deficits in neuron morphology and physiology - a link with lipid metabolism?From1 Aug 2017 → 31 Dec 2021Funding: FWO Strategic Basic Research Grant
Publications
1 - 8 of 8
- Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis(2023)
Authors: Diana Piol, Sandrine Da Cruz
Pages: 1355 - 1380 - Current Methods In ALS Research(2023)
Authors: Sandrine Da Cruz, Ludo Van Den Bosch
- Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation(2021)
Authors: Diana Piol, Sandrine Da Cruz
- Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB(2021)
Authors: Sandrine Da Cruz
Pages: 1089 - 1099 - HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells(2021)
Authors: Sandrine Da Cruz
Pages: 585 - + - Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72(2020)
Authors: Sandrine Da Cruz
Pages: 615 - 624 - Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS(2020)
Authors: Mariana Bravo-Hernandez, Takahiro Tadokoro, Michael R Navarro, Oleksandr Platoshyn, Yoshiomi Kobayashi, Silvia Marsala, Atsushi Miyanohara, Stefan Juhas, Jana Juhasova, Helena Skalnikova, et al.
Pages: 118 - + - Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs(2016)
Authors: Philip Van Damme, Sandrine Da Cruz
Pages: 535 - 550