Researcher
Sarah-Maria Fendt
- Disciplines (Flanders Institute for Biotechnology):Bioinformatics and computational biology, Molecular and cell biology, Oncology
- Disciplines (KU Leuven):Biochemistry and metabolism, Medical systems biology, Molecular and cell biology, Oncology
Affiliations
- Laboratory of Cellular Metabolism and Metabolic Regulation (VIB-KU Leuven) (Division)
Responsible
From1 Oct 2013 → Today - Fendt Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory of Cellular Metabolism and Metabolic Regulation (VIB-KU Leuven) (Division)
Member
From1 Jan 2013 → Today
Projects
1 - 10 of 34
- Dissecting the heterotypic cell communication networks at the perivascular niche to detect andintercept the early metastatic processFrom1 Jan 2023 → TodayFunding: BOF - iBOF
- Predicting metastasis formation based on cancer cells with a distinct energy metabolismFrom1 Oct 2022 → TodayFunding: BOF - projects
- Inhibiting iron metabolism to target metastasesFrom1 Oct 2022 → TodayFunding: BOF - projects
- Desorption electrospray ionization multi reflecting TOF: DESI XS SELECT SERIES MRTFrom2 Aug 2022 → TodayFunding: Other federal scientific institutions
- Imaging the invisible in preclinical models using magnetic particle imagingFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- Exploiting a novel link between metabolism and acetylation to predict and to treat metastasis formationFrom1 Jan 2022 → TodayFunding: FWO research project
- The role of zDHHC20 in breast cancer metastasis formationFrom5 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the role of metabolism in metastasizing breast cancer cellsFrom1 Oct 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Investigating the role of metabolism in metastasizing breast cancer cellsFrom1 Jul 2021 → 31 Oct 2022Funding: Other federal public and semi-governmental institutions
- The role of tumor microenvironment in promoting PHGDH loss-induced metastasis formationFrom19 Apr 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 106
- Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells(2022)
Authors: Anke Vandekeere, Sarah-Maria Fendt
Pages: 4537 - + - Serine auxotrophy: a novel metabolic vulnerability of platinum resistant ovarian cancers?(2022)
Authors: Tom Van Nyen, Frédéric Amant, Daniela Annibali, Sarah-Maria Fendt
- CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation.(2022)
Authors: Dorien Broekaert, Elodie Modave, Peter Carmeliet, Diether Lambrechts, Sarah-Maria Fendt
Pages: 111639 - Metabolite-derived protein modifications modulating oncogenic signaling(2022)
Authors: Anke Vandekeere, Sarah-Maria Fendt
- GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide(2022)
Authors: Juan Fernandez Garcia, Steven De Vleeschouwer, Raphael Sciot, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Frederik De Smet, Diether Lambrechts, Sarah-Maria Fendt
- PFKFB4 interacts with FBXO28 to promote HIF-1 alpha signaling in glioblastoma(2022)
Authors: Sarah-Maria Fendt
- Editorial overview: The metabolic network(2022)
Authors: Sarah-Maria Fendt
- PHGDH heterogeneity potentiates cancer cell dissemination and metastasis (vol 605. pg 747, 2022)(2022)
Authors: Margherita Demicco, Anke Vandekeere, Juan Fernandez Garcia, Carla Riera Domingo, David Nittner, Francesca Rizzollo, Panagiotis Karras, Dorien Broekaert, Sofie Demeyer, Ayse Bassez, et al.
Pages: E8 - E8 - Metastasis(2022)
Authors: Sarah-Maria Fendt
Pages: 787 - 791 - Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers(2022)
Authors: Ali Talebi, Wout De Wispelaere, Regina Esi Mensimah Baiden-Amissah, Guy Eelen, Emanuele Berardi, Johannes Swinnen, Peter Carmeliet, Diether Lambrechts, Sarah-Maria Fendt, Daniela Annibali, et al.