Researcher
Stefaan De Smedt
- Keywords:drug delivery, biotherapeutics
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanotechnology not elsewhere classified, Nanometrology, Other pharmaceutical sciences not elsewhere classified, In vitro testing, Biopharmaceuticals, Non-clinical studies, Biopharmaceutics, Pharmaceutical technology, Physical pharmacy, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nucleic acids, Gene and molecular therapy
Affiliations
- Board of Governors/Executive Board (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Laboratories of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Student Administration Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Responsible
From1 Oct 2010 → 30 Sep 2014 - Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2010 → 30 Sep 2014 - Department of Pharmaceutics (Department)
Member
From1 Oct 1996 → Today - Department of Pharmaceutical analysis (Department)
Member
From1 Oct 1992 → 30 Sep 1994
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
1 - 10 of 42
- A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccinesFrom7 Feb 2024 → TodayFunding: Foreign private sponsor - undefined
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Evaluation of formulation parameters o n the mRNA integrity within mRNA lipid nanoparticlesFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindnessFrom1 Nov 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Immunopeptidomics-based Development of Next-Generation Bacterial mRNA VaccinesFrom1 Jul 2023 → TodayFunding: HORIZON.2.1 - Health
- Laser-induced nanobubbles for advanced therapies in the eye.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-MsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapyFrom1 Oct 2022 → TodayFunding: BOF - projects
- Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.From1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
Publications
21 - 30 of 71
- Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts(2020)
Authors: Heyang Zhang, Koen Rombouts, Laurens Raes, Ranhua Xiong, Stefaan De Smedt, Kevin Braeckmans, Katrien Remaut
- Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation(2020)
Authors: Laurens Raes, Stephan Stremersch, Juan Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, et al.
- Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment(2020)
Authors: Yining Xu, Herlinde De Keersmaecker, Kevin Braeckmans, Stefaan De Smedt, Patrice D. Cani, Véronique Préat, Ana Beloqui
- Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling(2020)
Authors: Heyang Zhang, Dawei Hua, Chaobo Huang, Sangram Keshari Samal, Ranhua Xiong, Félix Sauvage, Kevin Braeckmans, Katrien Remaut, Stefaan De Smedt
- Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA(2019)
Authors: Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
- Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care(2019)
Authors: Eline Teirlinck, Juan Carlos Fraire, Heleen Van Acker, Jasper Wille, Rosalie Swimberghe, Toon Brans, Ranhua Xiong, Maarten Meire, Roeland De Moor, Stefaan De Smedt, et al.
- Three decades of messenger RNA vaccine development(2019)
Authors: Rein Verbeke, Ine Lentacker, Stefaan De Smedt, Heleen Dewitte
- Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells(2019)
Authors: Rein Verbeke, Ine Lentacker, Karine Breckpot, Jonas Janssens, Serge Van Calenbergh, Stefaan De Smedt, Heleen Dewitte
Pages: 1655 - 1669 - Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis(2019)
Authors: Molood Shariati, Wouter Willaert, Wim Ceelen, Stefaan De Smedt, Katrien Remaut
- Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells(2019)
Authors: Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, et al.
Patents
1 - 10 of 10
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method to increase the permeability of the plasma membrane of cells and a structure suitable for use in such method (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Composition for treatment of vitreous disease or disorder (Inventor)
- THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)