Researcher
Sylvia De Brakeleer
- Keywords:Medicine
- Disciplines:Genetic predisposition, Analysis of next-generation sequence data, Molecular diagnostics, Cancer biology, Genetics
Affiliations
- Clinical sciences (Department)
Member
From8 Apr 2019 → 28 Jun 2019 - Faculty of Medicine and Pharmacy (Faculty)
Member
From14 Aug 2015 → 28 Jun 2016 - Clinical sciences (Department)
Member
From1 Jan 2014 → 28 Jun 2019 - Laboratory for Medical and Molecular Oncology (Research group)
Member
From1 Jan 2010 → 22 Mar 2021 - Department of Embryology and Genetics (Department)
Member
From1 Mar 2003 → 31 Dec 2013
Publications
1 - 10 of 14
- CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition(2019)
Authors: Philippe Giron, Alfiah Noor, Rajendra Bahadur Shahi, Sylvia De Brakeleer, Carolien Eggermont, Hugo Vandenplas, Bram Boeckx, Diether Lambrechts, Jacques De Grève, Erik Teugels
Pages: 5933-5941 - The clinical characteristics of breast cancers with a familial risk in which no BRCA1/2 mutations were found are sometimes suggestive for a genetic etiology(2019)
Authors: Sofie Joris, Sylvia De Brakeleer, Pauwels Ingrid, Erik Teugels
- Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families(2019)
Authors: Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ingrid Pauwels, M Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels, Jacques De Grève
- Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer(2018)
Authors: Maxim Noeparast, Philippe Giron, Sylvia De Brakeleer, Carolien Eggermont, Ulrike De Ridder, Erik Teugels, Jacques De Grève
Pages: 16110-16123 - An alternative model for (breast) cancer predisposition(2017)
Authors: Erik Teugels, Sylvia De Brakeleer
- Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib(2016)
Authors: Maxim Noeparast, Erik Teugels, Philippe Giron, Gil Verschelden, Sylvia De Brakeleer, Lore Decoster, Jacques De Grève
Pages: 60094-60108 - Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients(2016)
Authors: Sylvia De Brakeleer, Jacques De Grève, C Desmedt, Sofie Joris, Christos Sotiriou, M. Piccart, I Pauwels, Erik Teugels
Pages: 336-340 - Parp inhibitors(2016)
Authors: Leen Vanacker, I. Pauwels, E. Denayer, Sylvia De Brakeleer, Erik Teugels
Pages: 263-275 - Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma(2015)
Authors: Isabelle Vande Broek, Françoise Majois, Jean-François Baurain, Sylvie Rottey, Andrée Rorive, Johan De Mey, Sylvia De Brakeleer
Pages: 6893-6899 - Detection of EGFR-TK Domain-activating Mutations in NSCLC With Generic PCR-based Methods(2015)
Authors: Rajendra Bahadur Shahi, Sylvia De Brakeleer, Jacques De Grève, Caroline Geers, Pieter in 't Veld, Erik Teugels
Pages: 163-171
Linked dataset
1 - 7 of 7
- Additional file 9: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 1: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 6: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 4: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 5: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 11: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)
- Additional file 3: of Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families (Creator)