Researcher
Tim Vervliet
- Disciplines:Cell death, Cell signalling, Molecular and cell biology not elsewhere classified, Cell physiology, Biochemistry and metabolism not elsewhere classified
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From15 Sep 2010 → Today
Projects
1 - 9 of 9
- 'Mito-tracking’ the phenotyping transition of pancreatic stellate cellsFrom1 Oct 2023 → TodayFunding: BOF - projects
- Unraveling the molecular mechanisms underlying Ca2+-signaling modulation by CISD2, a wolfram syndrome-associated gene, and its interplay with Bcl-2 (CaCISD2)From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Regulation of lysosomal function by ryanodine receptormediated Ca2+ release in health and diseaseFrom1 Oct 2020 → TodayFunding: FWO senior postdoctoral fellowship
- Targeting dysregulated IP3 receptor-mediated calcium signaling as an early event in Alzheimer’s disease through its Bcl-2-interaction networkFrom21 Sep 2020 → TodayFunding: FWO fellowships
- IP3R dysregulation as a proximal event in Alzheimer’s disease: exploring and exploiting Bcl-2 proteinsFrom1 Jan 2020 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Molecular mechanisms underlying Ca2+-signaling dysregulation in Wolfram SyndromeFrom1 Oct 2018 → 30 Sep 2020Funding: BOF - Bilateral scientific cooperation
- Elucidating the physiological and patho-physiological role for the interaction of Bcl-2 proteins and the ryanodine receptor.From1 Oct 2016 → 30 Sep 2019Funding: FWO fellowships
- Bcl-2 and ryanodine receptors: physiology, pathophysiology and therapeutics for the heartFrom1 Oct 2016 → 31 Aug 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
Publications
31 - 40 of 45
- Bcl-2 proteins and calcium signaling: complexity beneath the surface(2016)
Authors: Tim Vervliet, Jan Parys, Geert Bultynck
Pages: 5079 - 5092 - Novel function of Bcl-2/Bcl-XL proteins as regulators of ryanodine receptors(2015)
Authors: Tim Vervliet, Geert Bultynck, Jan Parys
Number of pages: 104 - Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation(2015)
Authors: Tim Vervliet, Jan Parys, Geert Bultynck
Pages: 396 - 404 - Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation(2015)
Authors: Tim Vervliet, Jan Parys, Geert Bultynck
Pages: 396 - 404 - Regulation of the ryanodine receptor by anti-apoptotic Bcl-2 is independent of its BH3-domain-binding properties(2015)
Authors: Tim Vervliet, Jan Parys, Geert Bultynck
Pages: 174 - 179 - Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain(2015)
Authors: Tim Vervliet, Elien Vandermarliere, Hristina Ivanova, Giovanni Monaco, Ludwig Missiaen, Humbert De Smedt, Jan Parys, Geert Bultynck
- Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival(2014)
Authors: Hristina Ivanova, Tim Vervliet, Ludwig Missiaen, Jan Parys, Humbert De Smedt, Geert Bultynck
Pages: 2164 - 2183 - Bcl-2 binds to and inhibits ryanodine receptors(2014)
Authors: Tim Vervliet, Ludwig Missiaen, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 2782 - 2792 - Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress(2013)
Authors: Santeri Kiviluoto, Tim Vervliet, Hristina Ivanova, Jean-Paul Decuypere, Humbert De Smedt, Ludwig Missiaen, Geert Bultynck, Jan Parys
Pages: 1612 - 1624 - IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2(2013)
Authors: Haidar Akl, Giovanni Monaco, Rita La Rovere, Santeri Kiviluoto, Tim Vervliet, Ludwig Missiaen, Jan Parys, Humbert De Smedt, Geert Bultynck