Researcher
Tom Desmet
- Keywords:biocatalysis, enzyme engineering, carbohydrate biotechnology
- Disciplines:Industrial molecular engineering of nucleic acids and proteins, Carbohydrates, Biocatalysis and enzyme technology
Affiliations
- Department of Biotechnology (Department)
Responsible
From1 Oct 2022 → Today - Department of Biotechnology (Department)
Member
From1 Oct 2022 → Today - Department of Biotechnology (Department)
Member
From1 Jan 2018 → Today - Department of Biochemical and microbial technology (Department)
Member
From1 Apr 2006 → 31 Dec 2017 - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2001 → 31 Mar 2006
Projects
1 - 10 of 32
- Oligosaccharide purification system – effective purification of short oligosaccharidesFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- The quest for an aldose C3-epimerase: the missing link in sugar conversionsFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Guided by Nature: enzyme tunnel evolution as a tool for functional adaptationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Off the beaten path of protein evolution: insertions and deletions as drivers of functional innovationFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Rational design and synthesis of non-hallucinogenic psilocin analogues as selective 5-HT2A receptor agonists with therapeutic potentialFrom1 Oct 2023 → TodayFunding: BOF - doctoral mandates
- Radical-based Enzymatic Degradation of Organic Pollutants (REDOP)From1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Cofunding core facility - HTS for SynBioFrom1 Jul 2022 → TodayFunding: BOF - research organisations
- MyCOS - Synthetic biology for a sustainable conversion of fungal chitin-rich waste streams into valuable biobased chitooligosaccharides for plant healthFrom1 Jan 2022 → 31 Dec 2023Funding: FWO Thematic call for research projects in the field of bioeconomy
- Evolution in practice: converting hydrolases and transferases into phosphorylasesFrom1 Nov 2021 → TodayFunding: FWO fellowships
- Unlocking the specificity determinants in nucleotide sugar epimerasesFrom1 Nov 2021 → TodayFunding: FWO fellowships
Publications
1 - 10 of 34
- High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase(2024)
Authors: Jorick Franceus, Manon Steynen, Yentl Allaert, Kato Bredael, Matthias D'hooghe, Tom Desmet
- Strategy for the enzymatic acylation of the apple flavonoid phloretin based on prior α-glucosylation(2024)
Authors: Jose L Gonzalez-Alfonso, Cristina Alonso, Ana Poveda, Zorica Ubiparip, Antonio O Ballesteros, Tom Desmet, Jesús Jiménez-Barbero, Luisa Coderch, Francisco J Plou
Pages: 4325 - 4333 - The conversion of UDP-Glc to UDP-Man : in silico and biochemical exploration to improve the catalytic efficiency of CDP-tyvelose C2-epimerases(2023)
Authors: Ulrike Vogel, Matthieu Da Costa, Carlos Alvarez Quispe, Henk‐Jan Joosten, Koen Beerens, Tom Desmet
- Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [18F] FDG yield potent sensors of living bacteria in vivo(2023)
Authors: Alexandre M. Sorlin, Marina López-Álvarez, Sarah J. Rabbitt, Aryn A. Alanizi, Rebecca Shuere, Kondapa Naidu Bobba, Joseph Blecha, Sasank Sakhamuri, Michael J. Evans, Kenneth W. Bayles, et al.
Pages: 17632 - 17642 - GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential(2022)
Authors: Koen Beerens, Ophelia Gevaert, Tom Desmet
- Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model(2022)
Authors: Amar Daniël Emanuel Van Laar, Charlotte Grootaert, Filip Van Nieuwerburgh, Dieter Deforce, Tom Desmet, Koen Beerens, John Van Camp
- Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65(2021)
Authors: Emma De Beul, Jorick Franceus, Tom Desmet
- Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol(2021)
Authors: Jorick Franceus, Zorica Ubiparip, Koen Beerens, Tom Desmet
Pages: 2777 - 2782 - Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering(2021)
Authors: Matthieu Da Costa, Ophelia Gevaert, Stevie Van Overtveldt, Joanna Lange, Henk-Jan Joosten, Tom Desmet, Koen Beerens
- Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion(2021)
Authors: Christian Rapp, Stevie Van Overtveldt, Koen Beerens, Hansjörg Weber, Tom Desmet, Bernd Nidetzky
Patents
1 - 6 of 6
- Mutant sucrose phosphorylases with improved glycosylation activity towards polyphenols (Inventor)
- A sucrose phosphorylase for the production of kojibiose (Inventor)
- Mutant sucrose phosphorylases with improved glycosylation activity towards polyphenols (Inventor)
- A sucrose phosphorylase for the production of kojibiose (Inventor)
- Mutant sucrose synthases and their uses (Inventor)
- System for adaptive drug delivery (Inventor)