Researcher
Tom Desmet
- Keywords:biocatalysis, enzyme engineering, carbohydrate biotechnology
- Disciplines:Industrial molecular engineering of nucleic acids and proteins, Carbohydrates, Biocatalysis and enzyme technology
Affiliations
- Department of Biotechnology (Department)
Responsible
From1 Oct 2022 → Today - Department of Biotechnology (Department)
Member
From1 Oct 2022 → Today - Department of Biotechnology (Department)
Member
From1 Jan 2018 → Today - Department of Biochemical and microbial technology (Department)
Member
From1 Apr 2006 → 31 Dec 2017 - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2001 → 31 Mar 2006
Projects
11 - 20 of 32
- Exploration of sucrose analogues enabled by enzyme and process engineeringFrom1 Oct 2021 → TodayFunding: BOF - projects
- Apiose exploration: reaction mechanism and applications of apiose-specific glycosyltransferasesFrom1 Oct 2021 → 31 Aug 2022Funding: BOF - postdoctoral mandates
- Stable and selective enzymes for the production of 2-GGFrom1 Aug 2021 → 31 Jul 2022Funding: IOF - technology concept exploration
- Automated protein purification: an essential step towards further analyses and new applications.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- Unlocking Synthetic Biology of Deoxy Sugars via Enzyme Engineering and Biocatalytic CascadesFrom1 Nov 2020 → 31 Oct 2021Funding: BOF - doctoral mandates
- Development of an inverting sucrose phosphorylase and its application for rare sugar production.From1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Phosphorylases as cost-efficient biocatalysts for carbohydrate synthesis: an exploration of natural and mutant diversityFrom1 Nov 2020 → 31 Oct 2021Funding: BOF - doctoral mandates
- DeoxyBioCat: Unlocking Synthetic Biology of Deoxy Sugars via Redesigned Biocatalytic CascadesFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Evolution at work: turning hydrolases into phosphorylases for the cost-efficient synthesis of glycosidic bonds.From1 Oct 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- Carbohydrate-based fine chemicals: Development of a glycosylation platform cell factory and optimization of downstream processing for the sustainable production of glycosidesFrom1 Jan 2018 → 30 Jun 2022Funding: H2020-EU.2.1.-INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies (LEIT)
Publications
1 - 10 of 34
- High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase(2024)
Authors: Jorick Franceus, Manon Steynen, Yentl Allaert, Kato Bredael, Matthias D'hooghe, Tom Desmet
- Strategy for the enzymatic acylation of the apple flavonoid phloretin based on prior α-glucosylation(2024)
Authors: Jose L Gonzalez-Alfonso, Cristina Alonso, Ana Poveda, Zorica Ubiparip, Antonio O Ballesteros, Tom Desmet, Jesús Jiménez-Barbero, Luisa Coderch, Francisco J Plou
Pages: 4325 - 4333 - The conversion of UDP-Glc to UDP-Man : in silico and biochemical exploration to improve the catalytic efficiency of CDP-tyvelose C2-epimerases(2023)
Authors: Ulrike Vogel, Matthieu Da Costa, Carlos Alvarez Quispe, Henk‐Jan Joosten, Koen Beerens, Tom Desmet
- Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [18F] FDG yield potent sensors of living bacteria in vivo(2023)
Authors: Alexandre M. Sorlin, Marina López-Álvarez, Sarah J. Rabbitt, Aryn A. Alanizi, Rebecca Shuere, Kondapa Naidu Bobba, Joseph Blecha, Sasank Sakhamuri, Michael J. Evans, Kenneth W. Bayles, et al.
Pages: 17632 - 17642 - GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential(2022)
Authors: Koen Beerens, Ophelia Gevaert, Tom Desmet
- Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model(2022)
Authors: Amar Daniël Emanuel Van Laar, Charlotte Grootaert, Filip Van Nieuwerburgh, Dieter Deforce, Tom Desmet, Koen Beerens, John Van Camp
- Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65(2021)
Authors: Emma De Beul, Jorick Franceus, Tom Desmet
- Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol(2021)
Authors: Jorick Franceus, Zorica Ubiparip, Koen Beerens, Tom Desmet
Pages: 2777 - 2782 - Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering(2021)
Authors: Matthieu Da Costa, Ophelia Gevaert, Stevie Van Overtveldt, Joanna Lange, Henk-Jan Joosten, Tom Desmet, Koen Beerens
- Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion(2021)
Authors: Christian Rapp, Stevie Van Overtveldt, Koen Beerens, Hansjörg Weber, Tom Desmet, Bernd Nidetzky
Patents
1 - 6 of 6
- Mutant sucrose phosphorylases with improved glycosylation activity towards polyphenols (Inventor)
- A sucrose phosphorylase for the production of kojibiose (Inventor)
- Mutant sucrose phosphorylases with improved glycosylation activity towards polyphenols (Inventor)
- A sucrose phosphorylase for the production of kojibiose (Inventor)
- Mutant sucrose synthases and their uses (Inventor)
- System for adaptive drug delivery (Inventor)