Researcher
Wim Van Hul
- Research Expertise:Genetic analyses of obesity and comorbidities and skeletal dysplasias
- Keywords:SKELETAL DYSPLASIAS, OBESITY, PAGET DISEASE, GENETIC DISEASE, Biomedical sciences (incl. biochemistry)
- Disciplines:Endocrinology and metabolic diseases, Molecular and cell biology, Metabolic diseases, Genetics
- Research techniques:DNA-sequencing, Next generation sequencing, cloning, expression studies, cell cultures, animal models (mouse and zebrafish)
- Users of research expertise:teams with complementary expertise and interest
Affiliations
- Medical Genetics (MEDGEN) (Research group)
Member
From1 Oct 2022 → Today - Medical genetics of obesity and skeletal disorders (MGENOS) (Research group)
Responsible
From1 Oct 2003 → 30 Sep 2022
Projects
1 - 10 of 27
- Precision Medicine Technologies (PreMeT)From1 Jan 2021 → TodayFunding: IOF - mandates
- Unraveling the Role of Paraoxonase 1 and 3 in the Etiology and Progression of Obesity and Obesity-Associated Liver Disease.From1 Nov 2020 → TodayFunding: FWO fellowships
- GENOmics in MEDicine: From whole genome sequencing towards personalized medicine (GENOMED).From3 Jul 2019 → TodayFunding: BOF - Methusalem, Fund Recuperation Fiscal Exemption
- The role of the paraoxonase gene family in obesity and obesity-associated liver disease following exposure to environmental pollutants or medical intervention strategies.From1 Jan 2019 → 31 Dec 2022Funding: BOF - projects
- Functional evaluation of the role of LRP4 and NPR3 in the regulation of bone metabolism by regulating respectively bone mass and bone growth.From1 Oct 2017 → 30 Sep 2020Funding: FWO fellowships
- Paget's disease of bone: molecular genetic investigation of the NFkB signaling regulating genes CBL, CBLB, and NR4A1 and functional validation in vitro and in Danio rerio.From1 Jan 2017 → 31 Dec 2020Funding: FWO Strategic Basic Research Grant
- Gene identification and zebrafish disease modeling of inherited bone disordersFrom1 Jan 2017 → 31 Dec 2021Funding: FWO scientific research network
- Study on the role of LRP4 in the regulation of Wnt signaling and bone formation.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- GENOMED - Genomics in Medicine.From1 Jan 2015 → 31 Dec 2019Funding: BOF - Other initiatives, Fund Recuperation Fiscal Exemption
- Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL).From1 Oct 2013 → 30 Sep 2018Funding: Health
Publications
11 - 20 of 177
- Rare heterozygous PCSK1 variants in human obesity(2022)
Authors: Evelien Van Dijck, Sigri Beckers, Sara Diels, Tammy Huybrechts, An Verrijken, Stijn Verhulst, Guy Massa, Wim Van Hul
Pages: 1 - 10 - Identification of compound heterozygous variants in LRP4 demonstrates that a pathogenic variant outside the third β-propeller domain can cause sclerosteosis(2022)
Authors: Yentl Huybrechts, Eveline Boudin, Gretl Hendrickx, Ellen Steenackers, Neveen Hamdy, Geert Mortier, Guillermo Martinez Diaz-Guerra, Milagros Sierra Bracamonte, Natasha M. Appelman-Dijkstra, Wim Van Hul
- Editorial: innovative therapies in bone biology(2022)
Authors: Elisabeth M.W. Eekhoff, Teun J. de Vries, Ralph J.B. Sakkers, Wim Van Hul
Pages: 1 - 3 - Broadening the spectrum of loss-of-function variants in NPR-C-related extreme tall stature(2022)
Authors: Peter Lauffer, Eveline Boudin, Daniëlle C.M. van der Kaay, Saskia Koene, Arie van Haeringen, Vera van Tellingen, Wim Van Hul, Timothy C.R. Prickett, Geert Mortier, Eric A. Espiner, et al.
- Camurati-Engelmann disease complicated by hypopituitarism(2022)
Authors: Liza Das, Vandana Dhiman, Pinaki Dutta, Ashwani Sood, Mahesh Prakash, Simran Kaur, Ellen Steenackers, Gretl Hendrickx, Devi Dayal, Wim Van Hul, et al.
Pages: 58 - 64 - Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking(2022)
Authors: Yentl Huybrechts, Wim Van Hul
Pages: 1 - 5 - A roadmap to gene discoveries and novel therapies in monogenic low and high bone mass disorders(2021)
Authors: Melissa M. Formosa, Dylan J.M. Bergen, Celia L. Gregson, Antonio Maurizi, Anders Kampe, Natalia Garcia-Giralt, Wei Zhou, Daniel Grinberg, Diana Ovejero Crespo, M. Carola Zillikens, et al.
- A panel-based sequencing analysis of patients with Paget's disease of bone suggests enrichment of rare genetic variation in regulators of NF-κB signaling and supports the importance of the 7q33 locus(2021)
Authors: Raphaël De Ridder, Geert Vandeweyer, Eveline Boudin, Gretl Hendrickx, Yentl Huybrechts, Tycho Canter Cremers, Jean-Pierre Devogelaer, Geert Mortier, Erik Fransen, Wim Van Hul
Pages: 656 - 665 - Further insights into the pathogenetic mechanisms of melorheostosis and Paget’s disease of bone(2021)
Authors: Raphaël De Ridder, Wim Van Hul, Geert Mortier
Number of pages: 216 - New insights in connective tissue and growth disorders(2021)
Authors: Silke Peeters, Geert Mortier, Wim Van Hul
Number of pages: 196