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Researcher

Winnok De Vos

  • Research interest  (University of Antwerp):- Cell biology of accelerated ageing diseases and neurodegeneration- Deep coverage microscopy for cellular profiling and drug screening
  • Keywords  (University of Antwerp):CELL BIOLOGY, NEURODEGENERATION, MICROSCOPICAL TECHNIQUES, CYTOSKELETON, IMAGE ANALYSIS, OXIDATIVE STRESS, LIGHT SHEET MICROSCOPY, LAMINS, AGEING, NUCLEUS, Applied biological sciences, biotechnology
  • Disciplines  (University of Antwerp):Computer vision, Image processing, Animal cell and molecular biology, Data visualisation and high-throughput image analysis, Single-cell data analysis, Cell death and senescence, Cytoskeleton, Intracellular compartments and transport, Molecular and cell biology not elsewhere classified, Biomedical image processing, Cell engineering, Molecular and cellular biomechanics, Biophotonics, Medical biophysics, Neurological and neuromuscular diseases, Neuroimaging
  • Disciplines  (Ghent University):Cell division, Transcription and translation, Cell growth and development, Molecular and cell biology not elsewhere classified, Cell death and senescence, Medical imaging and therapy not elsewhere classified, Cell movement, Cell signaling, Epigenetics, Animal cell and molecular biology
  • Research techniques  (University of Antwerp):Cell biology- Cell culture (cell lines, primary cultures, e.g., neurons) - Molecular techniques (qPCR, Western Blot, co-immunoprecipitation, cloning...)- Genetic manipulation (viral vectors, stable cell lines, CRISPR/CAS9)Advanced Light Microscopy- DNA/RNA sequence localisation with FISH (e.g., telomeres)- Protein localisation with immunofluorescence or live cell imaging- Functional assays: calcium imaging, ROS imaging, mitochondrial dynamics, DNA damage... - Photomanipulation (FRAP, foto-activatie)- High-throughput and high-content microscopy- Tissue clearing and light sheet microscopyBio-image Analysis- High-content cell-based image analyses (e.g., neuronal network connectivity, DNA damage spots...)- Data mining (statistics, clustering, classification...)- Simulations and benchmarking
  • Users of research expertise  (University of Antwerp):This expertise can be of use to any researcher interested in:- quantifying ageing phenomena at (sub-)cellular level (3D genome organisation, nuclear dysmorphy, oxidative stress, telomere shortening, DNA damage...)- qualitative and quantitative microscopy approaches at micro and mesoscale- genome manipulation and/or establishing relevant biological models- boosting the output from their image acquisition efforts - supporting biological image data sets by quantitative analyses - establishing robust, quantitative microscopy-based assays