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- Research interest:Our current research activities are related to the field of neurochemical research in neurodegenerative disorders. As coordinator of the RP-(U)HPLC unit of the Neurochemistry & Behavior lab, we perform neurotransmitter analyses in biofluids and brain material of patients with all types of dementia. Moreover, we have expertise in conducting behavioral research, and correlating these findings with neurotransmitter data. Our current projects are related to Alzheimer's disease in Down syndrome, Parkinson-plus syndromes, and frontotemporal dementia/amyotrophic lateral sclerosis. Our main goals are to (i) identify potential neurochemical biomarkers to facilitate differential diagnosis among these disorders, and (ii) to elucidate the neurochemical pathophysiology of neuropsychiatric symptoms in dementia. Our unit works closely with the neuropathology department of the Institute Born-Bunge, at which a large brain and biofluid biobank is situated. The UHPLC unit also functions as a service facility to analyze neurotransmitter levels in biofluids/brain material of various species. Our current setup is modifiable, to analyze various compounds.
- Keywords:BEHAVIOURAL NEUROSCIENCE, NEURODEGENERATIVE DISORDERS, NEUROPATHOLOGY, DOPAMINERGIC, HPLC ANALYSIS, BIOMARKER, SEROTONERGIC SYSTEM, NORADRENERGIC, Biomedical sciences (incl. biochemistry)
- Disciplines:Analytical separation and detection techniques, Medical biochemistry and metabolism not elsewhere classified, Clinical chemistry, Behavioural neuroscience, Neurological and neuromuscular diseases
- Research techniques:Neurochemical analytical research; ultra-high performance liquid chromatography with electrochemical detection (UHPLC-ECD); sample preparation skills; neuropathology; behavioral analytical research; behavioral assessment scales; biobanking; enzyme-linked immunosorbent assay
- Users of research expertise:All neuroscientists who wish to detect neurotransmitter levels in urine, cerebrospinal fluid, brain tissue or serum/plasma, among others: dopamine, serotonin, noradrenaline, adrenaline, tryptophane, MHPG, DOPAC, 5-HIAA, HVA.