Title Participants "Exergetic sustainability assessment of batch versus continuous manufacturing: lessons learned in primary and secondary pharmaceutical manufacturing" "Wouter De Soete" "Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD)" "Nils Bostijn, Jeroen Van Renterghem, Brecht Vanbillemont, W Dhondt, Chris Vervaet, Thomas De Beer" "Environmental sustainability assessment of batch versus continuous manufacturing : lessons learned in primary and secondary pharmaceutical manufacturing" "Wouter De Soete, Ana Gabriela Rentería Gámiz, Steven De Meester, Bert Heirman, Jo Dewulf" "Towards continuous pharmaceutical tablet manufacturing : implementation of continuous agglomeration techniques" "Valérie Vanhoorne" "Recent progress in continuous manufacturing of oral solid dosage forms" "Valérie Vanhoorne, Chris Vervaet" "Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed." "Continuous direct compression as manufacturing platform for sustained release tablets" "Bernd Van Snick, J. Holman, C. Cunningham, Ashish Kumar, Jurgen Vercruysse, Thomas De Beer, Chris Vervaet" "Control of three different continuous pharmaceutical manufacturing processes : use of soft sensors" "Jakob Rehrl, Anssi-Pekka Karttunen, Niels Nicolaï, Theresa Hoermann, Martin Horn, Ossi Korhonen, Ingmar Nopens, Thomas De Beer, Johannes G Khinast" "Process analytical technology for continuous manufacturing of solid-dosage forms" "Margot Fonteyne, Jurgen Vercruysse, Fien De Leersnyder, Bernd Van Snick, Chris Vervaet, Thomas De Beer" "A hybrid model for multipoint real time potency observation in continuous direct compression manufacturing operations" "Juan Pablo Gallo Molina, Giuseppe Cogoni, Elisabeth Peeters, Seshagiri Rao Ambati, Ingmar Nopens" "The ongoing transition from batch to continuous manufacturing offers both challenges and opportunities in the field of oral solid dosage form production. In turn, Process Analytical Technology (PAT) offers a path towards the successful deployment of continuous tablet manufacturing in rotary tablet presses. One promising PAT tool for this endeavour is the NIR-derived potency measurement. However, the high degree of noise in the data may hamper the extraction of useful information. For this reason, this work focused on the implementation of an adaptive Kalman filter algorithm that incorporates and reconciles the potency prediction given by one or more NIR probes with those of a semi-mechanistic compartmental model developed for the application at hand. This approach allowed for more robust concentration estimations. Furthermore, it was observed that potency levels in multiple locations in the studied tablet press (including those in the finished tablets) could be appropriately inferred using a single in-line measurement data stream. This methodology thus opens the door to advanced process control applications." "Model-based characterisation of twin-screw granulation system for continuous solid dosage manufacturing" "Ashish Kumar, Krist V Gernaey, Thomas De Beer, Ingmar Nopens" "Continuous twin-screw granulation has received increased attention as it can be embedded in a continuous manufacturing line allowing 24/7 production capacity eliminating scale-up requirements and intermediate storage. The screws have a modular structure (interchangeable transport and kneading discs) allowing greater flexibility in equipment design. However, process knowledge should be further developed both under steady state and dynamic conditions. Mechanistic models incorporating the underlying mechanisms are therefore applied. In this study, the principle constitutive mechanisms such as aggregation and breakage are included in a population balance modelling framework. Based on an experimental inflow granule size distribution and mean residence time of the granulator, predictions of the outflow granule size distribution were made. Experimental data was used for calibrating the model for individual screw modules in the twin-screw granulator. The results showed that the successive kneading blocks lead to a granulation regime-separation inside the twin-screw granulator. The first kneading block after wetting caused an increase in the aggregation rate, which was reduced after the second kneading block. The breakage rate increased successively along the length of the granulator. Such a physical separation between the granulation regimes will be promising for future design and advanced control of the continuous granulation process."