Projects
Imaging the link between metabotropic and ionotropic signaling in vivo KU Leuven
Radiocaine Imaging in Brugada Syndrome KU Leuven
The objective of this project is to use multimodal multiparametric radiocaine imaging for better diagnosis and risk analysis of BrS patients.
In vivo imaging and therapy using labeled antibody derivatives KU Leuven
Glycans play a central role in numerous events in cell-cell recognition, cell communication and cell mobility. Errors in glycan architecture and expression level can lead to pathologies such as cancer. Tumor Associated Carbohydrate Antigens (TACA) are specific glycans that can serve as biomarkers for tumor diagnostics as is already the case for carcinoembryogenic antigen (CEA). This project will focus on the xeno-glycan Neu5Gc ...
Synthesis and evaluation of radioligands for PDE7 imaging in addiction animal model University of Antwerp
Development of novel imaging tracers for proteolitic remodelling of the brain extracellular matrix following traumatic brain injury University of Antwerp
Design, synthesis and evaluation of new potent radioligands for PDE7 imaging in the brain. University of Antwerp
Rigid Motion Correction for Positron Emission Tomography Brain Imaging KU Leuven
During a positron emission tomography (PET) scan the subject is required to be completely stationary for the duration of the scan. Any motion of the subject will translate into motion blur in the final reconstructed image and may reduce the diagnostic value of the image. Motion during a PET scan can be classified into two main categories: non-rigid and rigid motion. Non-rigid motion deforms the subject and is primarily caused by motion in the ...
Synthesis and biological evaluation of carbon-11 and fluorine-18 labelled P2X7-receptor ligands for diagnosis of neurological diseases using positron emission tomography KU Leuven
Neurodegenerative brain diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and amyotrophic lateral sclerosis are associated with progressive neuronal cell loss and neuroinflammation. Neuroinflammatory processes can be described as a release of neurotoxic substances which accelerate disease progression. As the incidence of neurodegenerative disorders increases and treatment is in most cases only effective in the ...