Unraveling the role of the hypoxia factor HIF-2a in muscle atrophy. KU Leuven
Skeletal muscle is essential to life as it provides the mechanical power for locomotion and breathing. In our aging population, loss of muscle mass due to long- term inactivity is a major cause of morbidity and mortality. It is also a critical component of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and although the role of muscle in ALS is debated improving muscle functioning prolongs survival. Thus, preventing ...