The development of a metabolomics-based in vitro model for human hepatotoxicity University of Antwerp
In order to comply with the REACH-regulations (Registration Evaluation and Authorization of Chemicals) and to improve animal welfare, a human based in vitro model to investigate the hepatotoxicity of new chemical entities (NCEs) will be developed. The designed model is based on an innovative approach combining in vitro methodology with LC-MS metabolomics, a recent – omics domain that examines alterations in the endogenous metabolic profile of ...