Projects

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Antiseptic induced oral microbial massacres: a fast-food feast for oral pathogens? KU Leuven

Wim Teughels
Periodontology & Oral Microbiology

Each day, most of us brush their teeth and/or rinse their mouth with oral hygiene products that contain substances that kill bacteria (antiseptics). Unfortunately, often manual plaque removal by means of a toothbrush or interdental cleaning devices is not perfect. Consequently, dental plaque, a poly-microbial biofilm is left behind. It is well known that the used antiseptics will only kill the bacteria in the upper layers of these biofilms. ...

Antiseptic induced oral microbial massacres: a fast-food feast for oral pathogens? Ghent University

Nico Boon
Department of Biotechnology

Each day, most of us brush their teeth and/or rinse their mouth with oral hygiene products that
contain substances that kill bacteria (antiseptics). Unfortunately, often manual plaque removal by
means of a toothbrush or interdental cleaning devices is not perfect. Consequently, dental plaque, a
poly-microbial biofilm is left behind. It is well known that the used antiseptics will only kill the
bacteria in the upper layers ...

The effect of conservative treatment of temporomandibular disorders on somatic tinnitus. University of Antwerp

Willem De Hertogh
Movement Antwerp (MOVANT)
This project aims to improve the quality of care for patients suffering from tinnitus attributed to a temporomandibular dysfunction (TMD). This by verifying the effect of TMD treatment on tinnitus. As a next step, underlying working mechanisms of the applied treatment will be investigated (mediating factors). Third, variables that predict the treatment outcome (responders/ non-responders) will be analysed (prognostic indicators).Our findings wil ...

Biocompatibility and cariogenicity of resin-based dental materials. KU Leuven

Kirsten Van Landuyt
Environment and Health, Biomaterials - BIOMAT

To restore carious or traumatized teeth, a dentist can choose between two direct (plastic) restorative materials, i.e. amalgam (silver-colored) or composite (tooth-colored). To restrict environmental mercury pollution, the WHO (World Health Organization) currently encourages a global phasingdown of the use of dental amalgam. Tooth tissue lost due to trauma or caries is nowadays preferentially replaced with composite. After a widespread ...

Use of stereolithographic model in tooth autotransplantation and periodontal ligament stem cells for pulp revascularization and reinnervation to increase the success rate for tooth replacement in children KU Leuven

Reinhilde Jacobs
Oral and Maxillo-facial Surgery - Imaging & Pathology (OMFS-IMPATH)

Loss of permanent teeth is a particular challenge in children considering that alveolar bone growth is not yet complete and treatment approaches should adapt to both growth and developmental changes in the oral region to have the potential for long-term survival. This could be realized via autotransplantation, which is a biological approach for tooth replacement in young children. Key factor for its success is the preservation of the ...

The biological control of oral biofilms using Bdellovibrio bacteriovorus. KU Leuven

Wim Teughels
Periodontology & Oral Microbiology
The key problem in the treatment of oral infections, as for other medical infectious diseases and industrial applications is the formation and the effective removal of biofilms. The most ideal properties of a biological agent for the treatment of biofilm-associated infections are: (1) high specificity for the pathogenic bacteria, (2) not attacking non-pathogenic and non-bacterial cells, (3) attack a broad range of pathogenic bacteria, (4) be ...

Biocompatibility and cariogenicity of resin-based dental materials. KU Leuven

Kirsten Van Landuyt
Biomaterials - BIOMAT
Information regarding biocompatibility and cariogenicity of composite restorative materials ('tooth-colored fillings') is so far scare. As the polymerization of composites is never complete (the degree of polymerization is usually around 50-60%), it has been shown that several uncrued components may be released. Even though clinical observations are reassuring, several disturbing studies have been published, warning for possible biotoxic effects ...

Aging-resistant zirconia ceramic for dental restorations. KU Leuven

Jef Vleugels
Surface and Interface Engineered Materials, Biomaterials - BIOMAT
Zirconia ceramics are strong, tough and wear resistant and are used for orthopaedic implants since quite some time. Despite the susceptibility of zirconia to low temperature degradation ageing, i.e. the transformation of the metastable tetragonal to monoclinic ZrO2-phase in aqueous conditions at 20-250°C, zirconia ceramics are fast introduced for restoring and replacing teeth. So far, the dental community only reported minor shortcomings such as ...

Understanding mechanotransduction in mesenchymal stem cells by proteomics. Knowledge transfer to implant osseointegration. KU Leuven

Ignace Naert
Biomaterials - BIOMAT
Mechanical loading plays an important role in the maintenance and regeneration of bone tissue. The biological mechanisms by which bone adapt to loading are not fully understood. The project aims at investigating the protein expression pattern and their functions during mechanical loading of differentiating cells by means of mass spectrometry and imaging mass spectrometry. In the in vitro part of the project, a cell culture system generating ...