Projects
Reducing the burden of Pertussis disease in very young infants in different epidemiological settings through pertussis vaccination in pregnancy. University of Antwerp
Development, validation and application of complementary in vitro models for the prediction of in vivo clearance of drug candidates in specific populations. KU Leuven
Drug development is an extremely expensive undertaking due to lengthy and costly clinical trials. Unfortunately, numerous drug candidates with poor pharmacokinetics (i.e. short half-life, high clearance), unfavorable efficacy or unanticipated toxicity still fail in clinical development phases. To reduce attrition rates during late stage drug development, pharmaceutical companies have designed nonclinical evaluation programs which aim to ...
The role of microcirculatory dysfunction, the innate immune system and intestinal permeability in the early onset of acute-on-chronic liver failure. KU Leuven
Amongst digestive diseases, cirrhosis is the most common non-neoplastic cause of mortality in the Western world. Furthermore, its prevalence is likely to increase in the coming decades because of the increasing incidence of nonalcoholic fatty liver disease. In this project, we focused on the pathophysiology of acute-on-chronic liver failure (ACLF, chapter IA) to gain a further understanding of several of the lethal complications in cirrhosis: ...