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Genome and transcriptome engineering with CRISPR/Cas as a precision medicine for Charcot-Marie-Tooth type 2L. University of Antwerp

Vincent Timmerman
Peripheral Neuropathies Group
Patients with Charcot-Marie-Tooth disease (CMT) have a hereditary motor and sensory neuropathy causing a length-dependent degeneration of their peripheral nerves. Most patients have a duplication on chromosome 17 resulting in a higher expression of the peripheral myelin protein 22 (PMP22). Finding ways to reduce PMP22 expression has led to the development of a treatment for this group of patients. However, a significant number of CMT patients ...

Attentional deficits and postural alignment: providing new insights in the interaction between cognition and motor function after stroke. University of Antwerp

Nick Gebruers
Movement Antwerp (MOVANT)
Visuospatial neglect (VSN) is a neuropsychological cognitive condition characterized by an attention deficit to one side of the hemispace, often provoked by stroke. Patients with VSN fail to pay attention to the contralesional hemispace. Approximately 25-30% of stroke patients are confronted with VSN of which 40% still show VSN a year post-stroke. Patients with VSN need more time to recover from sensory-motor impairments, do not reach the same ...

Remote controlled miniaturized radiotracer injection device for dynamic PET imaging in free running small animals. University of Antwerp

Jeroen Verhaeghe
Molecular Imaging and Radiology (MIRA)
In this project, a miniaturized injection device will be developed. The injection device will be carried by a rat and will be operated by remote control to perform an intravenous bolus injection (0.5 ml / min) in the rat via a catheter in the jugular vein. The injection device will be used for the injection of a radio-tracer into the animal while being in the scanner during the dynamic brain imaging of awake, free-running animals. Since access ...

Characterization of HINT1 knockout Drosophila model for peripheral neuropathy. University of Antwerp

Kristien Peeters
VIB CMN - Molecular Neurogenomics
Recessive loss-of-function mutations in HINT1 rank among the leading causes of axonal peripheral neuropathy (Charcot-Marie-Tooth disease, CMT). They are associated with a severe, progressive and early-onset phenotype for which no curative treatment exists to date. HINT1 is a pleiotropic and evolutionary conserved purine phosphoramidase with unknown endogenous substrate(s) and its role in the peripheral nervous system is utterly unexplored. The ...

Transcriptomic profiling of amyloid-induced responses in central and enteric neuronal cultures. University of Antwerp

Peter Verstraelen
Laboratory of cell biology and histology
In recent years, growing evidence has been provided showing that disorders affecting the central nervous system (CNS) are accompanied or even preceded by neuropathological alterations in the enteric nervous system (ENS). This co-morbidity is well-described for Parkinson's disease and prion diseases, but it is still unclear whether the same holds true for disorders involving β-amyloid (Aβ) accumulation such as Alzheimer's disease (AD). Until now, ...

Using molecular proximity to refine synapse quantification in neuronal cultures. University of Antwerp

Alfonso Gerardo Garcia
Laboratory of cell biology and histology
Synapses are specialized connections between neuronal cells that determine the wiringpatterns, which are essential for memory and cognition. Synaptic dysfunction is a commonpathological hallmark of neurodevelopmental and - degenerative conditions. Thus, accurateand reliable quantification of synaptic state and number in neuronal networks is crucial. Inprevious work, we have shown that primary neuronal cultures from rodents preserve ...